研究のタイプ: 医学/生物学の研究 (experimental study)

Effects of power frequency alternating magnetic fields on reproduction and pre-natal development of mice. med./bio.

掲載誌: J Toxicol Sci 2002; 27 (3): 131-138

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研究目的(著者による)

To evaluate the effects of exposure to a 50 Hz magnetic field on reproduction and prenatal development in mice.

詳細情報

Male mice were exposed to 1) a sham exposure, 2) a 0.5 mT magnetic field, and 3) a 5.0 mT magnetic field for nine weeks to cover at least one complete spermatogenic cycle (35 animals per group). The same number of female mice was exposed to the same exposure groups, but only for two weeks. Afterwards, male mice were mated with females of the same exposure group in a ratio 1:1. Female mice were further exposed. On pregnancy day 18, a cesarean section was performed and embryos were examined (n=28/32/34 dams in groups 1/2/3). In non-pregnant females, uteri were also taken and examined.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 50 Hz
ばく露時間: males: continuously for at least 9 weeks; females: continuously for at least 32 days (expect for ca. 1 hour per day for caretaking)
ばく露2: 50 Hz
ばく露時間: males: continuously for at least 9 weeks; females: continuously for at least 32 days (expect for ca. 1 hour per day for caretaking)

ばく露1

主たる特性
周波数 50 Hz
タイプ
  • magnetic field
波形
  • sinusoidal
ばく露時間 males: continuously for at least 9 weeks; females: continuously for at least 32 days (expect for ca. 1 hour per day for caretaking)
ばく露装置
ばく露の発生源/構造
  • コイル
  • exposure source taken from reference
ばく露装置の詳細 no information given
Sham exposure A sham exposure was conducted.
Additional information background magnetic field for sham exposure was 0.1-1 µT
パラメータ
測定量 種別 Method Mass 備考
磁束密度 0.5 mT effective value - - -

ばく露2

主たる特性
周波数 50 Hz
タイプ
  • magnetic field
波形
  • sinusoidal
ばく露時間 males: continuously for at least 9 weeks; females: continuously for at least 32 days (expect for ca. 1 hour per day for caretaking)
ばく露装置
ばく露の発生源/構造
  • E1と同じ装置
パラメータ
測定量 種別 Method Mass 備考
磁束密度 5 mT effective value - - -

Reference articles

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露中
  • ばく露後

研究の主なアウトカム(著者による)

The body weight of male mice of group 2 (0.5 mT) was significantly lower on days 21 and 28 of exposure compared to the sham exposure group. However, this effect was only transient.
No other significant effects between the exposure groups and the sham exposure group were observed.
The authors conclude that exposure of mice to a 50 Hz magnetic field has no major effect on reproduction and prenatal development.

研究の種別:

研究助成

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