研究のタイプ: 医学/生物学の研究 (experimental study)

[SDラットのELF磁界の毒性学的評価] med./bio.

Developmental toxicity evaluation of ELF magnetic fields in Sprague-Dawley rats.

掲載誌: Bioelectromagnetics 2003; 24 (4): 231-240

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研究目的(著者による)

The effects of exposure of pregnant rats to a 60 Hz magnetic field on fertility and health of dams and teratogenic effects in fetuses should be investigated.

詳細情報

Mated female rats were divided into 4 groups (n=24 each): exposure to a magnetic field of 1) 5 µT, 2) 83.3 µT, 3) 500 µT and 4) sham exposure. On gestational day 20, all rats were anesthetized, Caesarean sections were conducted and dams and fetuses were investigated.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 60 Hz
ばく露時間: continuous for 22 h/day from day 6 to day 20 of gestation
ばく露2: 60 Hz
ばく露時間: continuous for 22 h/day from day 6 to day 20 of gestation
ばく露3: 60 Hz
ばく露時間: continuous for 22 h/day from day 6 to day 20 of gestation

ばく露1

主たる特性
周波数 60 Hz
タイプ
  • magnetic field
ばく露時間 continuous for 22 h/day from day 6 to day 20 of gestation
Additional information horizontally polarized
ばく露装置
ばく露の発生源/構造
チャンバの詳細 polycarbonate cages with polycarbonate lids
ばく露装置の詳細 field generator consisted of four square coils and one rack (1.8 m x 1.8 m x 1.8 m) with three animal living floors with more than 10 animals per floor in individual cages; magnetic field variation within the animal testing area was less than 3%; room maintained a temperature of 22 ± 3°C and a relative humidity of 50 ± 10%
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
磁束密度 5 µT - 測定値および計算値 - -

ばく露2

主たる特性
周波数 60 Hz
タイプ
  • magnetic field
ばく露時間 continuous for 22 h/day from day 6 to day 20 of gestation
Additional information horizontally polarized
ばく露装置
ばく露の発生源/構造
  • E1と同じ装置
パラメータ
測定量 種別 Method Mass 備考
磁束密度 83.3 µT - 測定値および計算値 - -

ばく露3

主たる特性
周波数 60 Hz
タイプ
  • magnetic field
ばく露時間 continuous for 22 h/day from day 6 to day 20 of gestation
Additional information horizontally polarized
ばく露装置
ばく露の発生源/構造
  • E1と同じ装置
パラメータ
測定量 種別 Method Mass 備考
磁束密度 500 µT - 測定値および計算値 - -

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露前
  • ばく露中
  • ばく露後

研究の主なアウトカム(著者による)

No significant differences were found between the exposure groups (groups 1-3) and the sham exposure group.
The authors conclude that exposure of pregnant rats to a 60 Hz magnetic field has no effects on fertility and health of dams and no teratogenic effects in fetuses.

研究の種別:

研究助成

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