研究のタイプ: 医学／生物学の研究 (experimental study)

Pre and post natal exposure of 50 Hz electromagnetic fields on prostate glands of rats: an electron microscopy study med./bio.

著者: Khaki AA, Khaki A, Garachurlou S, Khorshidi F, Tajadini N, Madinei N
掲載誌: Iran J Reprod Med 2008; 6 (2): 77-82
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研究目的（著者による）

The effect of prenatal and postnatal exposure of rats to a 50 Hz magnetic field on the prostate ultrastructure should be investigated.

詳細情報

From 50 pregnant rats, 30 were randomly selected after conception and exposed to the magnetic field while 20 others were not exposed. After birth, 30 newborns were randomly selected from exposed mothers and further exposed for 5 weeks (exposure group) and 20 newborns from the non-exposed mothers were used as a control group. Subsequently, 15 animals of each group were killed and examined.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 50 Hz
ばく露時間: 8 hours/day for approx. 3 weeks in utero and 5 weeks postnatal

ばく露1

主たる特性
周波数 50 Hz
タイプ
  • magnetic field
ばく露時間 8 hours/day for approx. 3 weeks in utero and 5 weeks postnatal
ばく露装置
ばく露の発生源／構造
ばく露装置の詳細 the exposure system consisted of two copper coils placed on top of each other and separated by a distance of 50 cm; a cylindrical wooden container was placed in the exposure area between the coils; inside this container was a chamber for keeping the animal cages; to prevent a temperature increase inside the chamber, a fan was fitted at the top and the temperature was checked; at a time two cages could be put within the chamber with 7-8 rats, respectively; all rats were free to move in the cage during exposure time; the temperature was the same for both control and exposed animals (20°C-30°C); relative humidity was monitored at 35-60% and a 12 hr light/dark cycle was provided
パラメータ
測定量 値 種別 Method Mass 備考
磁束密度 8 mT - 校正 - -

ばく露を受けた生物:

方法 影響評価項目／測定パラメータ／方法

研究対象とした生物試料:
調査の時期:
  • ばく露後

研究の主なアウトカム（著者による）

In the exposure group, there were several potentially pathological abnormalities, which were not observed in the control group. Among others, epithelial cells were generally inactive and cuboidal and their nuclei were dense. Corpora amylacea were more numerous. Smooth muscle fibers spread out in different directions with heterochromatic nuclei and mitochondria seemed dilated. The number of microvilli was decreased significantly.
The authors conclude that prenatal and postnatal exposure of rats to a 50 Hz magnetic field might have a deleterious effect on the prostate ultrastructure.

研究の種別:

研究助成

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