研究のタイプ: 医学／生物学の研究 (experimental study)

[携帯電話電磁界へのヒト末梢血リンパ球のばく露は染色体の不安定性をもたらす] med./bio.

Exposure of human peripheral blood lymphocytes to electromagnetic fields associated with cellular phones leads to chromosomal instability

著者: Mashevich M, Folkman D, Kesar A, Barbul A, Korenstein R, Jerby E, Avivi L
掲載誌: Bioelectromagnetics 2003; 24 (2): 82-90
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この研究は、インビトロで、ヒト末梢血リンパ球（PBL）に830 MHzの連続波電磁界のばく露を与え、染色体の損失または増加（異数性）が生じるか否かを調べた。PBLは、温度範囲が34.5〜37.5℃に保たれた平行平板共振器内に置かれ、いくつかのレベルのSAR（1.6 - 8.8 W/ kg）で、72時間のばく露を受けた。ばく露を受けた組織培養フラスコ内の平均SARとその分布は、測定値と数値解析を組み合わせて決定された。その結果、17番染色体の異数性の直線的な増加が、SAR値の関数として観察された；このことは、このばく露が遺伝毒性効果を持つことを示している；RF無ばく露の対照実験を34.5〜38.5℃の温度範囲で実施した場合、温度上昇は遺伝的またはエピジェニティックな変化のいずれにも関連しなかった、と報告している。

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研究目的（著者による）

To address the question whether in vitro exposure of human peripheral blood lymphocytes to mobile telephone frequencies (continuous 830 MHz) leads to genetic effects that are associated with increased risk for cancer.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 830 MHz
Modulation type: CW
ばく露時間: continuous for 72 h
  • 電力: 1 W maximum
  • SAR: 2 W/kg mean (unspecified) (± 0.3 W/kg)
  • SAR: 2.9 W/kg mean (unspecified) (± 0.3 W/kg)
  • SAR: 4.3 W/kg mean (unspecified) (± 0.2 W/kg)
  • SAR: 8.2 W/kg mean (unspecified) (± 0.6 W/kg)

ばく露1

主たる特性
周波数 830 MHz
タイプ
  • electromagnetic field
特性
  • guided field
ばく露時間 continuous for 72 h
Modulation
Modulation type CW
ばく露装置
ばく露の発生源／構造
  • parallel plate RF resonator, 6 cm long, 5 cm wide and 2.4 cm apart
チャンバの詳細 incubator
ばく露装置の詳細 The exposure cell consisted of a plastic standard tissue culture flask of 25 cm² that was placed within a parallel plate RF resonator fed by a coaxial cable through a tapered transition section.
Additional information The sham exposed sample was placed in the same incubator, at a different height level, with a metal plate between the two samples. An additional control flask was grown in a different incubator which was set to 37 °C.
パラメータ
測定量 値 種別 Method Mass 備考
電力 1 W maximum 測定値 - -
SAR 2 W/kg mean 測定値および計算値 unspecified ± 0.3 W/kg
SAR 2.9 W/kg mean 測定値および計算値 unspecified ± 0.3 W/kg
SAR 4.3 W/kg mean 測定値および計算値 unspecified ± 0.2 W/kg
SAR 8.2 W/kg mean 測定値および計算値 unspecified ± 0.6 W/kg
Additional parameter details

Since the exposure was not evenly distributed over the whole range, the samples were subdivided into four groups according to their average SAR level.

測定および計算の詳細

The RF power feeding the exposure cell was coupled by a directional coupler to an RF detector. The distribution of power density and SAR inside the exposure cell (including the incubator's wall effect) was computed by a finite element (HFSS) simulation code with a mesh resolution of ~1/6 of the wavelength in each medium and an accuracy estimated to be ±5%. For a 1 W input power computation, the maximum SAR in the culture is 24 W/kg, whereas the average power density is 9.4 W/kg. Results were supported by extensive temperature measurements.

ばく露を受けた生物:

方法 影響評価項目／測定パラメータ／方法

研究対象とした生物試料:
調査の時期:
  • ばく露後

研究の主なアウトカム（著者による）

The results indicate that human cells exposed to radiofrequency radiation acquire premalignant genotypes associated with elevated levels of aneuploidy and abnormalities in replication mode as expressed in asynchrony in the replication timing of homologous chromosomal regions associated with chromosome segregation.

研究の種別:

研究助成

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