研究のタイプ: 医学/生物学の研究 (experimental study)

[ラジオ周波数照射(900 MHz, GMSシグナル)はヒト末梢血リンパ球での微少核形成頻度ならびに細胞増殖に影響しない:実験室間研究] med./bio.

Exposure to radiofrequency radiation (900 MHz, GSM signal) does not affect micronucleus frequency and cell proliferation in human peripheral blood lymphocytes: an interlaboratory study.

掲載誌: Radiat Res 2006; 165 (6): 655-663

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研究目的(著者による)

To study whether 24 h exposure to radiofrequency electromagnetic fields similar to those emitted by mobile phones induces genotoxic effects and/or effects on cell cycle kinetics in cultured human peripheral blood lymphocytes.

詳細情報

Genotoxic effects were evaluated in lymphocyte cultures from 10 healthy donors. Positive controls were provided by using mitomycin C (0.033 µg/ml).
Two research groups were involved in the study: one at ENEA, Rome, and the other at CNR-IREA, Naples. Each laboratory tested five donors, and the resulting slides were scored by both laboratories.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 900 MHz
Modulation type: pulsed
ばく露時間: continuous for 24 h
  • SAR: 1 W/kg peak
  • SAR: 5 W/kg peak
  • SAR: 10 W/kg peak

ばく露1

主たる特性
周波数 900 MHz
タイプ
  • electromagnetic field
ばく露時間 continuous for 24 h
Modulation
Modulation type pulsed
Duty cycle 12.5 %
Repetition frequency 217 Hz
Additional information

GSM signal

ばく露装置
ばく露の発生源/構造
  • wire-patch cell (WPC)
チャンバの詳細 The exposure system consisted of four WPCs, each fed by a different power level in a blinded procedure. Two WPCs shielded by metal grid boxes were placed in each of two incubators (5% CO2 and 95% air). Each WPC or at least each incubator had a dummy culture Petri dish for temperature measurement.
ばく露装置の詳細 The WPC [Laval et al., 2000] consisted of two parallel plates (15 x 15 x 2.9 cm³), short-circuited at the edges by four posts. The outer conductor of the RF supply coaxial cable was connected to the top plate, and the inner conductor was connected to the ground plane. The temperature of the exposed samples was maintained at 36.9 ± 0.5°C by spiral coils with circulating water positioned on each plate. Four 35-mm Petri dishes containing 3 ml of diluted blood were placed inside the cell where the E-field distribution was quite uniform.
Sham exposure A sham exposure was conducted.
Additional information Six conditions were tested in duplicate: RF exposure at peak SARs of 0 (sham), 1, 5 and 10 W/kg, a positive (MMC-treated) control, and a negative (unexposed and untreated) control. Positive and negative controls were kept for 24 h in a third CO2 incubator at 37°C.
パラメータ
測定量 種別 Method Mass 備考
SAR 1 W/kg peak 測定値および計算値 - -
SAR 5 W/kg peak 測定値および計算値 - -
SAR 10 W/kg peak 測定値および計算値 - -

Reference articles

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

The data revealed no genotoxic or cytotoxic effects in the range of SAR values investigated. These findings were confirmed by two reserach groups and when the same slides were scored by two operators.

研究の種別:

研究助成

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