研究のタイプ: 医学/生物学の研究 (experimental study)

[900MHz電磁界ばく露を受けたラット肝臓での酸化ストレスに対するカフェイン酸フェネチルエステル(CAPE)の保護効果] med./bio.

The protective effect of caffeic acid phenethyl ester (CAPE) on oxidative stress in rat liver exposed to the 900 MHz electromagnetic field.

掲載誌: Toxicol Ind Health 2009; 25 (6): 429-434

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研究目的(著者による)

To study the possible protective effects of caffeic acid phenethyl ester (CAPE) on lipid peroxidation and the antioxidant enzyme activities in rat liver exposed to 900 MHz electromagnetic fields.

詳細情報

Male rats were divided into three groups (each n=10): 1) control group; 2) exposure group; 3) exposure + CAPE. CAPE was injected 30 days before exposure.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 900 MHz
Modulation type: CW
ばく露時間: continuous for 1 h/day for 30 days

ばく露1

主たる特性
周波数 900 MHz
タイプ
  • electromagnetic field
ばく露時間 continuous for 1 h/day for 30 days
Additional information rats were divided into three groups: i) sham control ii) RF exposure iii) CAPE + RF exposure
Modulation
Modulation type CW
ばく露装置
ばく露の発生源/構造
ばく露装置の詳細 rats kept in 12 cm long plastic tube cages with a diameter of 5.5 cm; cage positioned directly above the antenna
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
電力 2 W peak - - -
電力密度 1.04 W/cm² average over time 測定値 - -

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
研究対象とした臓器系:
  • liver
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

The enzyme activity of xanthine oxidase, catalase and the levels of lipid peroxidation were significantly increased in the exposure group compared to the control group, although these parameters were significantly decreased in the "CAPE + exposure" group (compared to the exposure group; similar values as the control group). The superoxide dismutase enzyme activity and glutathione peroxidase activity significantly decreased in the exposure group compared with the control group, although their levels were significantly increased in the "CAPE + exposure" group (compared to the exposure group; similar values as the control group).
The authors conclude that CAPE may prevent the electromagnetic field induced oxidative changes in liver by strengthening the antioxidant defense system (by reducing reactive oxygen species and increasing antioxidant enzyme activities).

研究の種別:

研究助成

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