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To study the effect of extremely low frequency electromagnetic fields on a variety of components of the human innate immune system in a standardized in vitro cellular model.
Human peripheral blood mononuclear cells, isolated from blood from six healthy volunteers, were stimulated with specific TLR2 and TLR4 ligands (lipopolysaccharides and/or Pam3Cys) , or with several microorganisms and subsequently exposed (at different time points after stimulation). The Toll-like receptor (TLR) family is an important factor in the fast first response to invading pathogens.
|周波数||20 Hz–5 kHz|
|ばく露時間||continuous for 30 min|
|チャンバの詳細||exposure system situated in a standard cell culture incubator|
|ばく露装置の詳細||double cylinder; inner cylinder with double copper wire solenoid coil; outer cylinder with windings on both ends to reduce fringe fields|
No significant difference in immune response, as reflected by different interleukin production could be detected after stimulation with LPS (TLR4 ligand), Pam3Cys (TLR2 ligand) or a panel of heat killed microorganisms (multiple TLR ligands). The authors conclude that under these experimental conditions, extremely low frequency electromagnetic fields did not modulate the innate immune response of human primary cells after TLR stimulation in vitro.