研究のタイプ: 医学/生物学の研究 (experimental study)

[超低周波電磁界ばく露はヒト末梢血単核細胞におけるToll様受容体シグナル伝達を変化させない] med./bio.

Extremely low frequency electromagnetic field exposure does not modulate toll-like receptor signaling in human peripheral blood mononuclear cells.

掲載誌: Cytokine 2011; 54 (1): 43-50

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研究目的(著者による)

To study the effect of extremely low frequency electromagnetic fields on a variety of components of the human innate immune system in a standardized in vitro cellular model.

詳細情報

Human peripheral blood mononuclear cells, isolated from blood from six healthy volunteers, were stimulated with specific TLR2 and TLR4 ligands (lipopolysaccharides and/or Pam3Cys) , or with several microorganisms and subsequently exposed (at different time points after stimulation). The Toll-like receptor (TLR) family is an important factor in the fast first response to invading pathogens.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 20 Hz–5 kHz
ばく露時間: continuous for 30 min

ばく露1

主たる特性
周波数 20 Hz–5 kHz
タイプ
  • magnetic field
ばく露時間 continuous for 30 min
ばく露装置
ばく露の発生源/構造
チャンバの詳細 exposure system situated in a standard cell culture incubator
ばく露装置の詳細 double cylinder; inner cylinder with double copper wire solenoid coil; outer cylinder with windings on both ends to reduce fringe fields
パラメータ
測定量 種別 Method Mass 備考
磁束密度 5 µT - 校正 - -
磁束密度 3 µT maximum 測定値 - DC ambient value

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

No significant difference in immune response, as reflected by different interleukin production could be detected after stimulation with LPS (TLR4 ligand), Pam3Cys (TLR2 ligand) or a panel of heat killed microorganisms (multiple TLR ligands). The authors conclude that under these experimental conditions, extremely low frequency electromagnetic fields did not modulate the innate immune response of human primary cells after TLR stimulation in vitro.

研究の種別:

研究助成

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