この研究は、マウスの自閉症スペクトラム障害（ASD）関連の行動パラメータに対する超低周波電磁界の周産期ばく露の影響を調べた。BALB/C雄マウスをばく露群（n=8）と対照群（n=9）に分けた。ばく露はヘルムホルツコイルを用い、妊娠最終週から出生後7日目まで与えた。行動テストで、社会性、新奇なものへの嗜好性、移動、不安、探索行動、運動協調、嗅覚を評価した。その結果、ばく露群では、正常な社会性および新奇なものへの嗜好性に欠如が見られたが、不安、移動、運動協調、嗅覚には変化がなかった；またばく露群では、探索行動の減少が見られた､と報告している。
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To investigate the effects of prenatal and neonatal exposure to extremely low frequency magnetic fields on some autism spectrum disorders-relevant behavioral parameters in mice.
Male mice were exposed (n=8) or sham exposed (n=9) in utero during the last gestational week and during the first week after birth. Behavioral tests were performed in the age of 8-11 weeks.
Sociability and the preference for social novelty was tested in the "Three-chambers social apparatus" which is a contruct with three chambers. In a first session, the mouse has the choice to spend time in a chamber with an unknown mouse or without another mouse, while in a second session the mouse can choose between a chamber with the "old mice" from the first session and a "new mouse".
Exploratory behavior was examined using the "Hole-Board", consisting in a wooden board with 16 holes. The number of head-dips into the holes was counted.
| ばく露 | パラメータ |
|---|---|
|
ばく露1:
50 Hz
ばく露時間:
continously during the last week of gestation and during the first week after birth
|
|
| 周波数 | 50 Hz |
|---|---|
| タイプ |
|
| 波形 |
|
| ばく露時間 | continously during the last week of gestation and during the first week after birth |
| ばく露の発生源／構造 | |
|---|---|
| ばく露装置の詳細 | each of the coils (diameter 40 cm, respectively) had 154 turns, and the coils were separated at a distance of 20 cm; a sinusoidal 50 Hz-current was passed through the magnet; magnetic force lines were parallel to the horizontal component of the local geomagnetic field |
| Sham exposure | A sham exposure was conducted. |
| 測定量 | 値 | 種別 | Method | Mass | 備考 |
|---|---|---|---|---|---|
| 磁束密度 | 1 mT | mean | 測定値 | - | - |
In the "Three-chambers social apparatus", sham exposed mice showed a normal behavior which means that they were significantly more interested in the first session in the unknown mouse than in the empty chamber. In the second session they spent significantly more time in the chamber with the "new mouse" than in the chamber with the "old mouse". In contrast, the exposed mice showed no significant differences in the time they spent in the different chambers in both sessions. Additionally, exposed mice showed a significantly decreased exploratory behavior compared to the sham exposed mice which was shown by a significantly lower number of head dips. No significant differences between the exposure and the sham exposure group were observed regarding anxiety, locomotion, motor coordination and olfactory abilities.
The authors conclude that the results of this study support the hypothesis of a link between exposure to extremely low frequency magnetic fields and autism spectrum disorders, but further research is necessary.
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