研究のタイプ: 医学/生物学の研究 (observational study)

[製鉄所の作業員における血清生化学的パラメータに対する電磁界の影響] med./bio.

Effect of Electromagnetic Field on Serum Biochemical Parameters in Steelworkers.

掲載誌: J Occup Health 1999; 41 (3): 177-180

この研究は、製鉄所の誘電ヒータ装置が発生する電磁界(50Hz、電界強度20V/m、磁界強度2A/m)に長期ばく露した作業員(n=64)の血清中の生化学的パラメータを評価した。調査対象の64人を就業期間により3群に分けた:3年未満(n=20)、3-10年(n=28)、>10年(n=16)。同じ工場の、電磁界ばく露のない職種の従業員から対照(n=25)を選出した。対象者1人当たり、全部で12回採血した(4週間に1回)。その結果、ばく露群で、総タンパク質、β-およびγ-グロブリンの濃度の低下、γ-グルタミルトランスペプチダーゼおよびリンゴ酸脱水素酵素の活性の低下が有意であった、などの所見を報告している。

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研究目的(著者による)

The effects of a chronic occupational exposure of steelworkers to a 50 Hz magnetic field on blood serum parameters should be investigated.

詳細情報

64 steelworkers employed at the same workplace with chronic occupational exposure were used as "cases" and were divided into the three following groups on the basis of their previous employment period: 1) up to 3 years (n=20, mean age=24.2 ± 6.5 years), 2) 3-10 years (n=28, mean age=36.2 ± 7.2 years) and 3) more than 10 years (n=16, mean age=38.8 ± 8.9 years). The control group (n=25, mean age=35.2 ± 9.9 years) consisted of workers from the same factory in capacities without occupational exposure to a magnetic field. A total of 12 blood samples was taken per subject, 1 sample every 4 weeks.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 50 Hz
ばく露時間: repeated daily exposure of 6.8 h/day (mean) from Monday to Friday, a total of 34 h/week for up to >10 years

ばく露1

主たる特性
周波数 50 Hz
タイプ
  • magnetic field
ばく露時間 repeated daily exposure of 6.8 h/day (mean) from Monday to Friday, a total of 34 h/week for up to >10 years
ばく露装置
ばく露の発生源/構造
  • induction heater
ばく露装置の詳細 subjects worked at a tool shop and heavy processing shop, where two induction heaters were located; shops were closed rooms with appropriate humidity, ventilation and temperature
パラメータ
測定量 種別 Method Mass 備考
電界強度 20 V/m - - - -
磁界強度 2 A/m - - - -
磁束密度 1.3 mT - - - induction-value of each heater, not specified

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
調査の時期:
  • ばく露中
  • ばく露後

研究の主なアウトカム(著者による)

The total protein level was significantly decreased in group 2 (exposed for 3-10 years), the β-globulin level was significantly decreased in all case groups and the γ-globulin level was significantly decreased in group 1 (exposed for up to 3 years) and group 2 compared to the control. The enzyme activity of aspartate aminotransferase was significantly increased, whereas gamma-glutamyltranspeptidase and malate dehydrogenase activities were significantly reduced in group 3 (exposed for more than 10 years) compared to the control. The total lipid level and the total cholesterol levels were both significantly decreased in groups 2 and 3 compared to the control. Moreover, the triglycerides and pre-β-lipoproteins levels were significantly decreased and the α-lipoproteins level significantly increased in group 3 compared to the control.
The authors conclude, that a chronic occupational exposure of steelworkers to a 50 Hz magnetic field could influence some blood serum parameters. The most distinct changes were found in workers who had been occupationally exposed for more than 10 years.

研究の種別:

研究助成

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