研究のタイプ: 医学/生物学の研究 (observational study)

[電力作業員での免疫マーカとODC活性] med./bio.

Immune markers and ornithine decarboxylase activity among electric utility workers.

掲載誌: J Occup Environ Med 2004; 46 (2): 104-112

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研究目的(著者による)

The effects of an occupational exposure of electric utility workers to a 60 Hz magnetic field on the immune system should be investigated.

詳細情報

60 male workers with employment in electric power generation (n=12), distribution (n=31) or utility maintenance and administration (n=17) of an electric utility participated in the study. Regardless of their employment, the subjects were divided into 4 groups (quartiles, n=15 each) according to the mean values of their personal magnetic field exposure: groups 1, 2, 3 and 4.
4 sampling trials were conducted during 1 year. In each trial, after a non-work baseline day and the following 3 working days, overnight urine samples were collected (days 0, 1, 2, and 3), respectively. This procedure was repeated quarterly over the year. Additionally, subjects provided a blood sample at the end of day 3 during their third quarter of participation.
Melatonin was investigated because of its immunostimulating effect.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 60 Hz
ばく露時間: continuous
group 1
ばく露2: 60 Hz
ばく露時間: continuous
group 2
ばく露3: 60 Hz
ばく露時間: continuous
group 3
ばく露4: 60 Hz
ばく露時間: continuous
group 4

ばく露1

主たる特性
周波数 60 Hz
タイプ
  • magnetic field
ばく露時間 continuous
Additional information group 1
ばく露装置
ばく露の発生源/構造
  • 詳細不明
ばく露装置の詳細 during the workdays of each sampling trial, subjects wore exposimeters at the waist during waking hours and placed bedside adjacent to the waist during sleeping to measure exposure and ambient light
Additional information (remark EMF-Portal: no information is given on exposure levels for the employment groups or on the subjects' actual exposure durations)
パラメータ
測定量 種別 Method Mass 備考
磁束密度 0.04 µT mean 測定値 - ± 0.01

ばく露2

主たる特性
周波数 60 Hz
タイプ
  • magnetic field
ばく露時間 continuous
Additional information group 2
ばく露装置
ばく露の発生源/構造
  • E1と同じ装置
  • 詳細不明
パラメータ
測定量 種別 Method Mass 備考
磁束密度 0.05 µT mean 測定値 - ± 0.01

ばく露3

主たる特性
周波数 60 Hz
タイプ
  • magnetic field
ばく露時間 continuous
Additional information group 3
ばく露装置
ばく露の発生源/構造
  • E1と同じ装置
  • 詳細不明
パラメータ
測定量 種別 Method Mass 備考
磁束密度 0.08 µT mean 測定値 - ± 0.01

ばく露4

主たる特性
周波数 60 Hz
タイプ
  • magnetic field
ばく露時間 continuous
Additional information group 4
ばく露装置
ばく露の発生源/構造
  • E1と同じ装置
  • 詳細不明
パラメータ
測定量 種別 Method Mass 備考
磁束密度 0.25 µT mean 測定値 - ± 0.2

Reference articles

  • Yost M (1999): [交番磁界のばく露基準:路面電車労働者における職業的測定]

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露中

研究の主なアウトカム(著者による)

The proliferation of white blood cells and NK cell numbers in the blood were significantly decreased among workers with the highest magnetic field exposure (group 4) compared to workers with the lowest MF exposure (group 1).
These effects were most distinct in probands with a reduced melatonin level, who showed additionally significantly decreased B cell and monocyte numbers compared to the rest of the population (remark EMF-Portal: the reduced melatonin level was brought into relation with the magnetic field but this was not statistically secured).
All other parameters did not show any significant associations with the magnetic field exposure.
The authors conclude that an occupational exposure of electric utility workers to a 60 Hz magnetic field might have an effect on the immune system although consequences for health are unknown.

研究の種別:

研究助成

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