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研究目的（著者による）
The effects of a chronic exposure of rats to a 900, 1800 or 2450 MHz electromagnetic field on the cognitive function, stress response and DNA damage in the brain should be investigated.
詳細情報
24 rats were divided into 4 groups (n=6 each): 1) sham exposure, exposure to electromagnetic fields of 2) 900 MHz, 3) 1800 MHz and 4) 2450 MHz.
影響評価項目
神経系への影響: cognitive function, Hsp70 protein expression and DNA damage in the rat brain
Distance between exposed object and exposure source
100 cm
チャンバの詳細
rats were restrained in closed boxes of 30 x 15 x 20 cm (l x b x h) divided into 4 compartments with few holes of 1 cm diameter
ばく露装置の詳細
6 animals at a time were exposed in GTEM cell of 220 x 120 x 80 cm (l x b x h); microwave chamber was lined with absorbers to minimize reflections; spectrum analyzer was used to ensure the uniformity of the field strength; GTEM cell was placed in a temperature-controlled room (22°C ± 2°C)
Rats of all exposure groups (2-4) showed a significant different behavior in all parameters of the elevated plus maze and Morris water maze compared to the sham exposure, indicating impaired learning, memory and spatial memory. The level of heat shock protein 70 was significantly increased in all exposure groups compared to the sham exposure, indicating an increased stress response in the brain. The comet assay revealed significantly more DNA damage in the brain in all exposure groups compared to the sham exposure. The authors conclude that a chronic exposure of rats to a 900, 1800 or 2450 MHz electromagnetic field might have a harmful effect on the brain.
