研究のタイプ: 医学／生物学の研究 (experimental study)

[GSM900 MHzへの全身ばく露はマウスの空間記憶に影響を及ぼす] med./bio.

Whole body exposure with GSM 900MHz affects spatial memory in mice

著者: Fragopoulou AF, Miltiadous P, Stamatakis A, Stylianopoulou F, Koussoulakos SL, Margaritis LH
掲載誌: Pathophysiology 2010; 17 (3): 179-187
RISフォーマットで参考文献をダウンロード

この実験研究は、マウス（Mus musculus Balb/c系統）にMorris 水迷路試験（海馬依存性空間記憶作業）の試行を4日間（4回訓練試行／日）訓練し、4日目の4つ目の訓練試行の後2時間休憩して空間記憶の評価試行を実施した。ばく露群および擬似ばく露群は各6匹。ばく露／擬似ばく露は、4日間とも訓練前の1時間、訓練中の4試行の間の15分間×3回、訓練後の10分間（最終日は、テスト試行前の2時間）であり、ばく露レベルはSAR値0.41から0.98W/Kgの範囲のGSM900MHzパルス電磁界。ばく露、迷路実験とも二重ブラインド条件で実施した。その結果、ばく露群は擬似ばく露群に比べ、訓練2－4日目めの最初の訓練を評価すると、前日までに獲得した空間記憶能力の維持が弱く（脱出時間と水泳距離が大きい）、また最終評価試行でも目標への優先性を示さなかったと報告している。

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研究目的（著者による）

To study the effects of mobile phone exposure on spatial learning and memory in mice.

詳細情報

24 mice were divided into one exposure group and one sham exposure group (each n=12). The mice were trained to find a submerged escape platform located in a fixed position during four consecutive daily sessions (see Morris water maze). Each session consisted of four trials (with four different starting positions). Each trial had a maximum duration of 60 s and at the end of each trial the animals were allowed to remain on the platform for 20 s. Subsequently, they were returned to their home cage and left there to rest for 15 min before the beginning of the next trial. Exposure or sham exposure was continued during the intervals between the trials.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 900 MHz
Modulation type: pulsed
ばく露時間: 1 h 55 min. for the first 3 days (1 h prior to the first trial, 3 x 15 min. between trials, 10 min. after the last trial); 3 hr 45 min. on the fourth days (1 h prior to the first trial, 3 x 15 min. between trials, 2 h prior to the probe trial)
  • 電界強度: 23 V/m minimum (inside the cages)
  • 電界強度: 36 V/m maximum (inside the cages)
  • 電力密度: 0.05 mW/cm² minimum (inside the cages)
  • 電力密度: 0.2 mW/cm² maximum (inside the cages)
  • SAR: 0.41 W/kg minimum (whole body)
  • SAR: 0.98 W/kg maximum (whole body)

ばく露1

主たる特性
周波数 900 MHz
タイプ
  • electromagnetic field
特性
  • near field
ばく露時間 1 h 55 min. for the first 3 days (1 h prior to the first trial, 3 x 15 min. between trials, 10 min. after the last trial); 3 hr 45 min. on the fourth days (1 h prior to the first trial, 3 x 15 min. between trials, 2 h prior to the probe trial)
Modulation
Modulation type pulsed
ばく露装置
ばく露の発生源／構造
  • セルラ－電話
  • GSM handset
ばく露装置の詳細 mobile phone handset placed under the 267 mm x 207 mm x 140 mm Plexiglas cage
Sham exposure A sham exposure was conducted.
パラメータ
測定量 値 種別 Method Mass 備考
電界強度 23 V/m minimum 測定値 - inside the cages
電界強度 36 V/m maximum 測定値 - inside the cages
電力密度 0.05 mW/cm² minimum 測定値 - inside the cages
電力密度 0.2 mW/cm² maximum 測定値 - inside the cages
SAR 0.41 W/kg minimum 計算値 whole body -
SAR 0.98 W/kg maximum 計算値 whole body -

ばく露を受けた生物:

方法 影響評価項目／測定パラメータ／方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露中
  • ばく露後

研究の主なアウトカム（著者による）

The data revealed that during learning sessions, exposed animals showed a deficit in transferring the acquired spatial information across training days (i.e. an increased escape latency was found and an increased distance swam, compared to the sham exposed animals, on the first trial of training days 2-4). Moreover, during the memory probe trial (i.e. absence of the platform) sham exposed animals showed the expected preference for the target quadrant, while the exposed animals showed no preference, indicating that the exposed mice had deficits in memory consolidation and/or retrieval of the learned spatial information.
These data showed that exposure of mice to electromagnetic fields emitted by a mobile phone at SAR values within the ICNIRP guidelines affects the spatial learning and memory function in Balb/c mice.

研究の種別:

研究助成

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