研究のタイプ: 医学/生物学の研究 (experimental study)

[3G携帯電話の2100MHz無線周波放射と脳内のDNA酸化的損傷] med./bio.

The 2100 MHz radiofrequency radiation of a 3G-mobile phone and the DNA oxidative damage in brain.

掲載誌: J Chem Neuroanat 2016; 75 Pt B: 94-98

この研究は、雌ラットを、2つの2100MHz無線周波放射(RFR)ばく露群とそれぞれの擬似ばく露対照群に分け、2つのばく露群は、6時間/日、週5日のばく露をそれぞれ、2週間(ばく露日数10日)または8週間(同40日)与えた。ばく露終了後に、脳のゲノム含有DNAを抽出し、酸化的DNA損傷およびマロンジアルデヒドMDA)を分析した。その結果、脳の酸化的DNA損傷は、それぞれの対照群に比べ10日ばく露群では増加、40日ばく露群では減少した;40日ばく露群ではMDAの減少も観察された、と報告している。

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研究目的(著者による)

The effects of exposure of rats to a 2100 MHz electromagnetic field on oxidative stress and DNA damage in the brain should be investigated.

詳細情報

Female rats were divided into the following groups: 1) exposure to the electromagnetic field for 2 weeks (n=9), 2) sham exposure for 2 weeks (n=6), 3) exposure to the electromagnetic field for 8 weeks (n=9), 4) sham exposure for 8 weeks (n=6). Two days after the last respective (sham) exposure, the rats were anesthetized, killed and examined.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 2,100 MHz
ばく露2: 2,100 MHz

ばく露1

主たる特性
周波数 2,100 MHz
タイプ
  • electromagnetic field
特性
  • far field
Modulation
Modulation type cf. additional information
ばく露装置
ばく露の発生源/構造
Distance between exposed object and exposure source 12 cm
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
電界強度 16 V/m - 測定値 - -
SAR 0.4 W/kg - 計算値 whole body -

ばく露2

主たる特性
周波数 2,100 MHz
タイプ
  • electromagnetic field
特性
  • far field
Modulation
Modulation type cf. additional information
ばく露装置
ばく露の発生源/構造
  • E1と同じ装置
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
電界強度 16 V/m - 測定値 - -
SAR 0.4 W/kg - 計算値 whole body -

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

The amount of oxidative DNA damage was significantly increased after two weeks of exposure (group 1) compared to the control group (group 2), whereas no differences were found in lipid peroxidation.
After 8 weeks of exposure (group 3), oxidative DNA damage as well as lipid peroxidation were significantly reduced compared to the control group (group 4).
The authors conclude that an acute exposure of rats to a 2100 MHz electromagnetic field could cause oxidative DNA damage in the brain. However, chronic exposure could also lead to the adaptation and stimulation of DNA repair mechanisms.

研究の種別:

研究助成

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