研究のタイプ: 医学/生物学の研究 (experimental study)

[B6C3F1マウスに対する超低周波電磁界の影響] med./bio.

Effects of extremely low-frequency electromagnetic fields (ELF-EMF) exposure on B6C3F1 mice.

掲載誌: Environ Health Prev Med 2015; 20 (4): 287-293

この研究は、マウスの腫瘍発生および繁殖力に対する超低周波電磁界の長期ばく露の影響を調べた。C57BL/6NCrj妊娠マウス(n=10)に50Hzの磁界(500mG)のばく露を1日12時間、1週間与え、それらから生まれたB6C3F1マウス(雄24匹、雌42匹)をばく露群として、さらに15.5ヶ月間、同じばく露を与えた。対照群として、無ばく露妊娠マウス(n=10)から生まれた雄30匹、雌32匹を無ばく露で同じ期間観察した。その結果、ばく露群の平均体重は雄、雌とも対照群に比べ有意に低かった;肝臓および肺の腫瘍発生率への影響は無かった;雌において、慢性骨髄性白血病発生率対照群に比べばく露群で有意に高かった;精細管の大きさが対照群に比べばく露群で有意に小さかった、と報告している。

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研究目的(著者による)

The effects of a chronic exposure of mice to a 50 Hz magnetic field on the incidence of cancer, organ weights and male fertility should be investigated.

詳細情報

The offspring of 10 pregnant mice, which were exposed to the magnetic field during their last week of pregnancy until birth, were used as the exposure group (n=66). The offspring was further exposed after birth for 15.5 months. The offspring of 10 pregnant mice without exposure used for control group (n=62).

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 50 Hz
ばく露時間: continuous for 12 hours per day for 1 week before birth (in utero) and 15.5 months after birth

ばく露1

主たる特性
周波数 50 Hz
タイプ
  • magnetic field
ばく露時間 continuous for 12 hours per day for 1 week before birth (in utero) and 15.5 months after birth
ばく露装置
ばく露の発生源/構造
  • 詳細不明
チャンバの詳細 wire cages
ばく露装置の詳細 environmental conditions were 23 ± 2°C and 50 ± 10% humidity
パラメータ
測定量 種別 Method Mass 備考
磁束密度 50 µT - - - -

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
調査の時期:
  • ばく露中
  • ばく露後

研究の主なアウトカム(著者による)

The body weight and weight of the liver of exposed animals were significantly decreased compared to the control group.
In exposed animals, the incidence of chronic myeloid leukemia was significantly greater compared to the control group.
The seminiferous tubules diameter was significantly reduced in exposed animals in comparison to the control group.
The authors conclude that a chronic exposure of mice to a 50 Hz magnetic field might increase the incidence of chronic myeloid leukemia and could have a detrimental effect on the male fertility.

研究の種別:

研究助成

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