研究のタイプ: 医学/生物学の研究 (experimental study)

[ヒト末梢血単核細胞におけるROS誘導に対する900MHz電磁放射の影響] med./bio.

Effect of 900 MHz Electromagnetic Radiation on the Induction of ROS in Human Peripheral Blood Mononuclear Cells.

掲載誌: J Biomed Phys Eng 2015; 5 (3): 105-114

この研究は、900MHz GSM電磁界ばく露によるヒト末梢血単核細胞単球およびリンパ球)での酸化ストレス誘導および細胞内活性酸素種ROS)レベルの変化を調べた。健康なボランティア(n=13:21-30歳)から採取した末梢血の試料(6ml)をそれぞれ2分し、一方は携帯電話シミュレータから放射されるRF電磁界に2時間ばく露し、他方は対照(無ばく露)とした。ばく露後に各試料から単核細胞を遠心分離し、単球およびリンパ球細胞内ROS含有量を測定した。その結果、単球の豊富な試料では、ばく露群でのROS産生の有意な増加が見られた;リンパ球の豊富な試料では、このような影響は見られなかった、と報告している。

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研究目的(著者による)

The effects of exposure of human blood samples to a 900 MHz electromagnetic field (GSM) on oxidative stress in monocytes and lymphocytes should be investigated.

詳細情報

Blood samples were obtained from 13 healthy volunteers. Each sample was divided and one half was assigned to an exposure group (group 1) and the other half to a control group (group 2). After exposure, enriched fractions of monocytes and lymphocytes were investigated, respectively.
A positive control was conducted.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 900 MHz
Modulation type: pulsed
ばく露時間: continuous for 2 hours

ばく露1

主たる特性
周波数 900 MHz
タイプ
  • electromagnetic field
波形
  • pulsed
ばく露時間 continuous for 2 hours
Additional information signal bandwidth was 200 kHz
Modulation
Modulation type pulsed
Pulse width 463 µs
Duty cycle 12.5 %
Repetition frequency 217 Hz
ばく露装置
ばく露の発生源/構造
チャンバの詳細 6 well dishes
ばく露装置の詳細 the signal was generated by a GSM simulator and transferred to a rectangular waveguide made of aluminum by a co-axial wire; the samples were placed at a location with maximum electric and magnetic fields in the waveguide to provide a relatively homogeneous field for exposure; the increase of temperature was not more than 0.1°C
パラメータ
測定量 種別 Method Mass 備考
電力 2 W - - - -

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

Monocytes in the exposure group (group 1) showed a significantly increased content of reactive oxygen species compared to the control group (group 2). No significant differences between both groups were found in lymphocytes.
The authors conclude that exposure of human blood samples to a 900 MHz electromagnetic field (GSM) might induce oxidative stress in monocytes, although the consequences for health are not clear.

研究の種別:

研究助成

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