この研究は、雄ラットを用いて、超低周波電磁界ばく露（ELF:周波数3Hzおよび60Hz、4日連続の2時間／日ばく露を2日の間隔をおいて2回繰り返した；強度はアブストラクトに不記載）が記憶、不安様行動、電気生理学的特性、全脳のプロテオームに影響するか否かを調べた。短期記憶および不安様行動をばく露終了の直後、１および2週間後に評価した。また短期ばく露の影響を調べるため、2時間ばく露の直後に電気生理学的に評価した。その結果、一連のばく露終了直後の行動テストでは、擬似ばく露群に比べ3Hzおよび60Hzばく露群の両方において運動活動が低下した；不安様行動および短期記憶への影響は観察されなかった；2時間ばく露の直後では、3Hzおよび60Hzばく露群の両方において、青斑核の発火率が有意に低下した；一連のばく露処置後のプロテオーム解析で、全脳プロテオームの全体的変化が見られた､と報告している。
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The effects of exposure of male rats to a 3 Hz or 60 Hz electro-magnetic field on memory, anxiety and neuronal activity in the brain should be investigated.
A total of 90 rats were divided into 3 groups: 1) exposure to the 3 Hz magnetic field (n=30), 2) exposure to the 60 Hz magnetic field (n=30) and 3) sham exposure (n=30). For further 23 rats used in neuronal activity investigations, the subdivision is not clear.
| ばく露 | パラメータ |
|---|---|
|
ばく露1:
3 Hz
ばく露時間:
2 hours/day during 2 exposure trails of 4 days each, separated by an interval of 2 days
only for anxiety-like behavior tests
|
|
|
ばく露2:
3 Hz
ばく露時間:
continuous for 2 hours
|
|
|
ばく露3:
60 Hz
ばく露時間:
2 hours/day during 2 exposure trails of 4 days each, separated by an interval of 2 days
only for anxiety-like behavior tests
|
|
|
ばく露4:
60 Hz
ばく露時間:
continuous for 2 hours
|
|
| 周波数 | 3 Hz |
|---|---|
| タイプ |
|
| ばく露時間 | 2 hours/day during 2 exposure trails of 4 days each, separated by an interval of 2 days |
| Additional information | only for anxiety-like behavior tests |
| ばく露の発生源／構造 |
|
|---|---|
| チャンバの詳細 | plastic cage without any metallic cover in shielded room |
| ばく露装置の詳細 | the antenna was placed at the center of an aluminum mesh shielded room with dimensions of 1.5 m Œ 2 m Œ 2 m; the center of the animal cage was placed at a distance of 40 cm from effective radiative surface of the antenna on a wooden stage with a distance of 50 cm from the ground; room temperature was kept at 23 ± 2.0°C |
| Sham exposure | A sham exposure was conducted. |
| 測定量 | 値 | 種別 | Method | Mass | 備考 |
|---|---|---|---|---|---|
| 磁束密度 | 4 mT | - | 校正 | - | - |
| 周波数 | 3 Hz |
|---|---|
| タイプ |
|
| ばく露時間 | continuous for 2 hours |
| ばく露の発生源／構造 |
|
|---|---|
| Sham exposure | A sham exposure was conducted. |
| 測定量 | 値 | 種別 | Method | Mass | 備考 |
|---|---|---|---|---|---|
| 磁束密度 | 4 mT | - | 校正 | - | - |
| 周波数 | 60 Hz |
|---|---|
| タイプ |
|
| ばく露時間 | 2 hours/day during 2 exposure trails of 4 days each, separated by an interval of 2 days |
| Additional information | only for anxiety-like behavior tests |
| ばく露の発生源／構造 |
|
|---|
| 測定量 | 値 | 種別 | Method | Mass | 備考 |
|---|---|---|---|---|---|
| 磁束密度 | 4 mT | - | 校正 | - | - |
| 周波数 | 60 Hz |
|---|---|
| タイプ |
|
| ばく露時間 | continuous for 2 hours |
| ばく露の発生源／構造 |
|
|---|
| 測定量 | 値 | 種別 | Method | Mass | 備考 |
|---|---|---|---|---|---|
| 磁束密度 | 4 mT | - | 校正 | - | - |
Directly after exposure, the locomotor activity of rats in both exposure groups (groups 1 with 3 Hz and group 2 with 50 Hz) was significantly decreased compared to the sham exposure group. Moreover, a significant reduction in the action potential rate of brain neurons was found in both exposure groups compared to the sham exposure group.
Proteome analysis in the brain revealed changes in protein expression, but no specifications on significance and affected genes were given.
All other parameters did not show any significant differences between the groups.
The authors conclude that exposure of rats to a 3 Hz or 60 Hz electro-magnetic field might affect motor activity and neuron action potential rate in the brain.
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