研究のタイプ: 医学/生物学の研究 (experimental study)

[ラットの行動に対する超低周波電磁界(100μT)の影響] med./bio.

Effects of extremely low frequency electromagnetic fields (100 µT) on behaviors in rats.

掲載誌: Neurotoxicology 2016; 52: 104-113

この研究は、成獣雄ラット(n=60)を無作為に擬似ばく露群と超低周波電磁界(ELF-EMFばく露群に等分し、ELF-EMFばく露群には50Hz、100μTのELF-EMFの24週間ばく露を実施した。24週間のばく露(または擬似ばく露)中、体重および餌と飲料水の摂取量を記録した。また終了後に行動テストを実施した(不安行動:オープンフィールド試験、高架十字迷路試験、抑うつ行動:尾懸垂試験、強制水泳試験認知記憶の能力:モーリス水迷路試験、恐怖条件づけ試験)。その結果、体重および餌と飲料水の摂取量にばく露の影響は見られなかった;擬似ばく露群に比べ、ELF-EMFばく露群で何らかの不安行動および抑うつ行動が引き起こされることは何もなかった;認知および記憶能力がELF-EMFばく露により損なわれることはなかった、と報告している。

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研究目的(著者による)

The effects of exposure of rats to a 50 Hz magnetic field on the behavior, cognitive functions and brain histology should be investigated.

詳細情報

60 rats were equally divided into two groups: exposure and sham exposure. After (sham) exposure, both groups were divided into 3 subsets (n=10 each) to minimize the impact from the testing time and the prior testing. One subset of the animals was subjected to the tests in the order of open field test, tail suspension test and Morris water maze, meanwhile, another subset was subjected to the elevated plus maze and forced swim test subsequently. The last subset of both groups was subjected to the fear conditioning test. After these tests, all animals were killed and the brains examined.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 50 Hz
ばく露時間: continuous for 20 hours/day for 24 weeks

ばく露1

主たる特性
周波数 50 Hz
タイプ
  • magnetic field
ばく露時間 continuous for 20 hours/day for 24 weeks
ばく露装置
ばく露の発生源/構造
  • 詳細不明
チャンバの詳細 polycarbonate ventilated cages (45 cm x 20 cm x 35 cm, L x W x H), changed every 2 weeks
ばく露装置の詳細 exposure device (200 cm x 70 cm x 200 cm, L x W x H) was constructed with ABS plastics and utilized bronze wires; a four floors plastic shelf with a size of 140 cm x 70 cm x 200 cm (L x W x H) was placed inside the device; 45-55% relative humidity and 22-25°C room temperature were maintained
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
磁束密度 100 µT - 測定値 - -

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露中
  • ばく露後

研究の主なアウトカム(著者による)

No significant differences in any parameter were found between exposed and sham exposed rats.
The authors conclude that exposure of rats to a 50 Hz magnetic field has no effects on the behavior, cognitive functions and brain histology.

研究の種別:

研究助成

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