研究のタイプ: 医学/生物学の研究 (experimental study)

Effects of exposure to 50 Hz, 1 Gauss magnetic field on reproductive traits in male albino rats. med./bio.

掲載誌: Acta Vet Brno 2011; 80 (1): 107-111

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研究目的(著者による)

The effects of exposure of male rats to a 50 Hz magnetic field on fertility should be investigated.

詳細情報

Male rats were divided into 4 groups (n=7 each): Rats were either killed immediately and examined after exposure to investigate acute effects (group 1) or 48 days after exposure to detect delayed effects (group 2). Each exposure group had its own sham exposure group (groups 3 and 4).

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 50 Hz
ばく露時間: continuous for 21 days

ばく露1

主たる特性
周波数 50 Hz
タイプ
  • magnetic field
波形
  • sinusoidal
ばく露時間 continuous for 21 days
ばく露装置
ばく露の発生源/構造
チャンバの詳細 plastic cages with food and water containers
ばく露装置の詳細 a homogenous magnetic field was generated by 4 solenoids of 270 turns of electrically insulated 2.2 mm copper wire, respectively, wound around a copper cylindrical chamber of 55 cm external diameter; rats were placed at the center of the solenoids in their cages; animals were kept in a 12 h light/12 h dark cycle, at constant temperature of 25 °C
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
磁束密度 100 µT - 測定値 - ± 10 µT

Reference articles

  • Ali FM et al. (2003): [アルビノラットのRBCおよび心臓機能に対する50 Hz、0.2 mT磁界の影響]

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露前
  • ばく露後

研究の主なアウトカム(著者による)

There was a significant decrease in testes weights, sperm motility, sperm count, percentages of normal sperms and live sperms as well as in the enzyme activities of superoxide dismutase and catalase in the exposure groups (groups 1 and 2) compared to the respective sham exposure groups (groups 3 and 4). The alpha-tocopherol level was significantly decreased and serum testosterone and L-ascorbate levels were significantly increased directly after exposure (group 1) compared to the sham exposure group, but not after further 48 days (group 2).
Histopathological examination of the testes showed a disruption in its architecture with an increase in Leydig cell number and activity in group 1 compared to the sham exposure, whereas in group 2, there were high rates of apoptosis in the germ cell layers compared to the sham exposure.
The authors conclude that exposure of male rats to a 50 Hz magnetic field might impair fertility related parameters via oxidative stress.

研究の種別:

研究助成

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