研究のタイプ: 医学/生物学の研究 (experimental study)

[アルビノラットのRBCおよび心臓機能に対する50 Hz、0.2 mT磁界の影響] med./bio.

Effect of 50 Hz, 0.2 mT magnetic fields on RBC properties and heart functions of albino rats.

掲載誌: Bioelectromagnetics 2003; 24 (8): 535-545

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研究目的(著者による)

The effects of exposure of rats to a 50 Hz magnetic field on the ECG and red blood cells should be investigated.

詳細情報

Rats were divided into 4 groups (n=6 each): 1) exposure to the magnetic field for 15 days, 2) exposure to the magnetic field for 30 days, 3) exposure to the magnetic field for 30 days and subsequent keeping without exposure for further 45 days, 4) sham exposure (remark EMF-Portal: the sham exposure duration is not stated).

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 50 Hz
ばく露時間: continuous for 15 days
ばく露2: 50 Hz
ばく露時間: continuous for 30 days

ばく露1

主たる特性
周波数 50 Hz
タイプ
  • magnetic field
波形
  • sinusoidal
ばく露時間 continuous for 15 days
ばく露装置
ばく露の発生源/構造
チャンバの詳細 plastic cages (about 2000 cm2 surface area)
ばく露装置の詳細 a homogenous magnetic field was generated by four solenoids made of 270 turns of electrically insulated 2.2 mm copper wire each, wound around a copper cylindrical chamber of 55 cm external diameter; plastic cages were placed in the center of solenoids; water was pumped in a copper jacket separating the wire winding and the chamber in order to keep the temperature of the chamber constant during the exposure period (thermometer-controlled); current passing in the solenoids was about 2 A; an earthed copper mesh was used to cover both ends of the cage
Sham exposure A sham exposure was conducted.
Additional information the sham exposure group was kept in a similar cage and in an identical chamber, which was well grounded
パラメータ
測定量 種別 Method Mass 備考
磁束密度 200 µT effective value 測定値 - ± 10 µT

ばく露2

主たる特性
周波数 50 Hz
タイプ
  • magnetic field
波形
  • sinusoidal
ばく露時間 continuous for 30 days
ばく露装置
ばく露の発生源/構造
  • E1と同じ装置
パラメータ
測定量 種別 Method Mass 備考
磁束密度 200 µT effective value 測定値 - ± 10 µT

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露前
  • ばく露後

研究の主なアウトカム(著者による)

Groups 2 and 3 showed significant changes in the ECG compared to the sham exposure group.
A decreased cell membrane elasticity and permeability of red blood cells were observed in groups 1-3 compared to the sham exposure group. The cell morphological investigation confirmed changes in the membranes of groups 2 and 3. The dielectric properties of hemoglobin were different in groups 1-3 in comparison to the sham exposure group, indicating structural changes of hemoglobin in the exposed cells.
The authors conclude that exposure of rats to a 50 Hz magnetic field might impair the cell membrane of red blood cells with possibly detrimental consequences for the cardiovascular system.

研究の種別:

研究助成

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