研究のタイプ: 医学／生物学の研究 (experimental study)

[パルス状900 MHzマイクロ波の低レベル照射はマウスの空間学習行動をさまたげない] med./bio.

Low-level exposure to pulsed 900 MHz microwave radiation does not cause deficits in the performance of a spatial learning task in mice

著者: Sienkiewicz ZJ, Blackwell RP, Haylock RG, Saunders RD, Cobb BL
掲載誌: Bioelectromagnetics 2000; 21 (3): 151-158
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この研究は、217 Hzでパルス化された低レベルの900 MHz無線周波（RF）電磁界への反復的な急性ばく露が、食餌動機づけの空間学習タスクおよびワーキングメモリタスクに及ぼす影響を調べた。実験には、成獣オスのC57BL/6Jマウスを用いた。GTEMセル内での遠方界条件で、全身平均SAR 0.05 W/kgのばく露を、10日間、毎日45分間与えた。8本の放射状迷路タスクの遂行成績を、擬似ばく露対照群と比較した。全ての行動の評価者は、マウスのばく露の有無に関してブラインド化された。マウスは、ばく露（または擬似ばく露）の直後または15分後または30分後に迷路タスクの試験を受けさせられた。その結果、選択の正確さ、またはタスクの完遂に要した総時間において、電磁界がタスク遂行成績に与えた有意な影響は見られなかった、と報告している。

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研究目的（著者による）

To determine if a repeated, acute exposure of mice to a pulsed 900 MHz microwave signal that correspond to the GSM signature could be effective in altering the acquisition and performance of a learned behavioral task in a radial arm maze.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 900 MHz
Modulation type: pulsed
ばく露時間: repeated daily exposure, 45 min/day for 10 days
  • 電界強度: 45 V/m mean (± 6%)
  • SAR: 0.05 W/kg mean (whole body) (0.042-0.055 W/kg)

ばく露1

主たる特性
周波数 900 MHz
タイプ
  • electromagnetic field
特性
  • far field
ばく露時間 repeated daily exposure, 45 min/day for 10 days
Modulation
Modulation type pulsed
Pulse width 576 µs
Rise time 2 µs
Fall time 2 µs
Repetition frequency 217 Hz
ばく露装置
ばく露の発生源／構造
  • GTEMセル
チャンバの詳細 Animals were individually confined in Perspex cages (14 x 5 x 5 cm) limiting their movement without explicit restraint. Three of the small cages were secured to a Perspex base plate which fitted closely within a container (34 x 20 x 12.5 cm) of twin wall, corrugated polypropylene.
ばく露装置の詳細 The box was positioned centred along the mid-line of the cell so that the animals were placed mid-way between septum and floor which had a separation of 90 cm at this point.
パラメータ
測定量 値 種別 Method Mass 備考
電界強度 45 V/m mean 測定値 - ± 6%
SAR 0.05 W/kg mean 推定値 whole body 0.042-0.055 W/kg
Additional parameter details

Based on the SAR estimates, the absorbed energy per pulse had a range of 0.19 to 0.25 mJ/kg, with a mean of 0.23 mJ/kg.

測定および計算の詳細

The output voltage of the amplifier measured by means of a coaxial RF millivoltmeter was used by the control system to adjust the signal source output level to keep exposures within ± 0.6 V/m of the target. A field uniformity of better than ±10% across the volume occupied by the animals was confirmed by measurements made using a single axis probe utilising an electrically short dipole and diode detector and a 3-axis E-field probe. The dominant field component was vertical. The whole-body SAR was estimated using data for a prolate spheroid model of a mouse in the K orientation.

ばく露を受けた生物:

方法 影響評価項目／測定パラメータ／方法

研究対象とした生物試料:
調査の時期:
  • ばく露後

研究の主なアウトカム（著者による）

No significant field-dependent effects on performance were found in choice accuracy or in total times to complete the task across the experiment. These data suggest that exposure to radiofrequency radiation simulating a GSM signal under the conditions of this experiment does not affect the acquisition of the learned response.

研究の種別:

研究助成

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