研究のタイプ: 医学/生物学の研究 (experimental study)

[ラットの空間学習及び記憶に対する長期的な電磁界ばく露の影響] med./bio.

Effects of long-term electromagnetic field exposure on spatial learning and memory in rats.

掲載誌: Neurol Sci 2013; 34 (2): 157-164

この研究は、ラットの空間学習及び記憶に対する電磁界の長期ばく露の影響を調べた。迷路タスクの訓練を受けた32匹のWistarラットばく露群(916MHz、10W/m2の携帯電話電磁界に6時間/日、5日/週、10週間ばく露)と擬似ばく露群に分けた。毎週末、両群のラットに8方向放射迷路で食べ物を探すタスクを行わせ、完了時間、エラー総数、タスク中におけるニューロンの信号発火(両群からそれぞれ1匹を選び、海馬領域に植え込んだ微小電極から記録)を調べた。その結果、実験の4-5週目で、ばく露群では対照群と比較して、平均完了時間の延長及びエラー発生率の上昇が認められた(p<0.05);1-3週及び6-9週目では両群のこれらの値は同等であり、適応が示されたのかも知れない;全実験期間中、ばく露群の方が対照群より、海馬ニューロンの不規則な発火パターンとより短いスパイク間隔でのより多くのスパイク発火を示した、などの所見を報告している。

The detailed summary of this article is not available in your language or incomplete. Would you like to see a complete translation of the summary? Then please contact us →

研究目的(著者による)

To study the effect of electromagnetic fields on spatial learning and memory in rats.

詳細情報

32 pre-trained rats were divided into an exposure group and a control group. Three rats from each group were implanted electrode arrays in their hippocampal CA1 regions, but neuron signals from only one exposed rat in 9 weeks and one control rat in 8 weeks were recorded because electrode arrays fell off or rats bit off cables.
Rats were exposed from Monday to Friday and tests were performed on Saturday.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 916 MHz
ばく露時間: continuous for 2 x 3 h/day (6 h/day), 5 days/week, 10 weeks
  • 電力密度: 10 W/m² (near the center of the four cages)

General information

Rats were divided into an exposure group and a control group.

ばく露1

主たる特性
周波数 916 MHz
タイプ
  • electromagnetic field
ばく露時間 continuous for 2 x 3 h/day (6 h/day), 5 days/week, 10 weeks
ばく露装置
ばく露の発生源/構造
  • モノポール
チャンバの詳細 antenna was close to the exposure cages 1-4
ばく露装置の詳細 rats were exposed in four Makrolon cages (47 cm x 31 cm x 26 cm)
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
電力密度 10 W/m² - - - near the center of the four cages

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露前
  • ばく露中
  • ばく露後

研究の主なアウトカム(著者による)

The data showed that during the weeks 4-5 of the experiment, the average completion time and error rate of the exposure group were longer and larger than that of the control group, i.e. compared with the control group, the exposed animals spent more time in the maze and made more mistakes during weeks 4-5.
The hippocampal neurons showed irregular firing patterns and more spikes with a shorter interspike interval for both the exposure and the control group during the whole experiment period.
The findings indicate that the 916 MHz electromagnetic field exposure influence learning and memory in rats to some extent at a specific exposure time point and that the rats can adapt to long-term electromagnetic field exposure.

研究の種別:

研究助成

関連論文