研究のタイプ: 医学/生物学の研究 (experimental study)

[無線周波電磁放射の慢性ばく露を受けた思春期前のラットでの空間認知変化に関する可能性のある原因] med./bio.

Possible cause for altered spatial cognition of prepubescent rats exposed to chronic radiofrequency electromagnetic radiation.

掲載誌: Metab Brain Dis 2015; 30 (5): 1193-1206

この研究は、4週齢雄ウィスターラット無線周波電磁放射RF-EMR;900MHz;SAR 1.15W/kg、電力密度ピーク値146.60μW/cm2)を1日1時間、28日間のばく露を与え、その後、空間認知行動テスト(モーリスの水迷路テスト)および海馬組織検査を実施した。その結果、ばく露群では、前進的な学習能力が低下した;また、訓練の24時間後に行った記憶保持テストで小さな空間記憶障害がみられた;海馬に構造的変化がみられた、などの所見を報告している。

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研究目的(著者による)

The effects of a chronic exposure of rats to a 900 MHz electromagnetic field on spatial memory and the neural structure in the hippocampus should be investigated.

詳細情報

Rats were divided into the following groups: 1) exposure to the electromagnetic field (n=24), 2) sham exposure (n=24) and 3) cage control (n=24).

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 900 MHz
ばく露時間: continuous for 1 h/day for 28 days
  • 電力: 2 W (according to manufacturer)
  • SAR: 1.15 W/kg (according to manufacturer)
  • 電力密度: 146.6 µW/cm² (3 cm away from mobile phone)

ばく露1

主たる特性
周波数 900 MHz
タイプ
  • electromagnetic field
ばく露時間 continuous for 1 h/day for 28 days
ばく露装置
ばく露の発生源/構造
  • セルラ-電話
チャンバの詳細 polypropylene cages (41 Œ 28 Œ 14 cm)
ばく露装置の詳細 an activated mobile phone (silent mode, giving unattended calls (50 calls/h) with the help of an auto dialer) was inserted in a wire mesh cage (12 Œ 7 Œ 7 cm) and placed at the center of the animal cage (n=3 rats per cage)
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
電力 2 W - - - according to manufacturer
SAR 1.15 W/kg - - - according to manufacturer
電力密度 146.6 µW/cm² - 測定値 - 3 cm away from mobile phone

Reference articles

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露前
  • ばく露後

研究の主なアウトカム(著者による)

There were no significant differences in the body weight between the groups.
Learning and the spatial memory were significantly deteriorated in rats exposed to the electromagnetic field compared to cage control and sham exposure groups.
No cellular aggregates were found in any group, but neuronal cell viability was significantly decreased in exposed rats compared to cage control and sham exposure rats. Moreover, pyramidal cells of exposed rats showed significantly less dendritic arborization compared to the cage control group.
The authors conclude that chronic exposure of rats to a 900 MHz electromagnetic field could impair spatial memory and the neural structure in the hippocampus and they propose a causal relationship.

研究の種別:

研究助成

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