研究のタイプ: 医学／生物学の研究 (experimental study)

[2.4 GHz WiFi信号への全身ばく露：アルツハイマー病の三重トランスジェニックマウス・モデル（3xTg-AD）での認知障害への影響] med./bio.

Whole body exposure to 2.4 GHz WIFI signals: Effects on cognitive impairment in adult triple transgenic mouse models of Alzheimer's disease (3xTg-AD)

著者: Banaceur S, Banasr S, Sakly M, Abdelmelek H
掲載誌: Behav Brain Res 2013; 240: 197-201
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この研究は、2.40GHzのWi-Fi信号への長期ばく露の影響を評価した動物研究である。野生種のマウスおよびアルツハイマー病に類似した認知障害を発症するようにした三重トランスジェニックマウス（3xTg-AD）を、比吸収率（SAR）1.60W/kgの無線周波（RF）信号に2時間／日、1ヵ月間ばく露したそれぞれのマウスのばく露群および擬似ばく露群は各7匹とした。ばく露終了後、3種類の認知行動テストを実施した。その結果、3xTg-ADマウスのRFばく露群において、認知行動の改善が見られた、と報告している。

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研究目的（著者による）

To study the effects of a 4-week exposure to a 2.4 GHz WiFi signal on transgenic mice carrying mutations linked with Alzheimer's disease.

詳細情報

Triple transgenic mice with three human genes associated with Alzheimer's disease were used: Amyloid Beta Precursor protein (APP sw), Presenilin 1 (PS1M146V), and tau P301L. The non transgenic mice (wild type) had the same genetic backround as the transgenic mice.
Mice were divided into four groups (each group n = 7): two groups of transgenic mice (exposed and sham exposed), and two groups of wild type mice (exposed and sham exposed).

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 2.4 GHz
ばく露時間: continuous for 2 h/day on 28 days
  • SAR: 1.6 W/kg

General information

Mice were divided into the following four groups: i) transgenic mice sham exposed ii) transgenic mice EMF exposed iii) wild type mice sham exposed iv) wild type mice EMF exposed

ばく露1

主たる特性
周波数 2.4 GHz
タイプ
  • electromagnetic field
ばく露時間 continuous for 2 h/day on 28 days
ばく露装置
ばく露の発生源／構造
  • antenna
Distance between exposed object and exposure source 26 cm
ばく露装置の詳細 cages with the mice positioned in a circular pattern around the antenna with each cage approximately 26 cm from the antenna; exposure system placed in a Faraday cage
Sham exposure A sham exposure was conducted.
パラメータ
測定量 値 種別 Method Mass 備考
SAR 1.6 W/kg - - whole body -

ばく露を受けた生物:

方法 影響評価項目／測定パラメータ／方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露中

研究の主なアウトカム（著者による）

The data demonstrated that radiofrequency exposure improved cognitive behavior of transgenic mice in the Dark/Light-Box test and the Barnes maze. Exposure to the WiFi signals reduced the latency and made the transgenic mice less anxious. No effects on locomotor activity, body weight or body temperature were found.
The authors conclude that radiofrequency exposure may represent an effective memory-enhancing approach in Alzheimer's disease.

研究の種別:

研究助成

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