Home
Medical/biological study (experimental study)

Evidence for mobile phone radiation exposure effects on reproductive pattern of male rats: role of ROS.

Published in: Electromagn Biol Med 2012; 31 (3): 213-222

Aim of study (acc. to author)

To examine whether a GSM signal effects the reproductive pattern by targeting the biochemistry of sperm.
Background/further details: Two experiments were performed. For the first experiment, male rats were divided into a sham exposure or an exposure group (n=6 per group). Blood was collected immediately after exposure for a testosterone assay. Immediately after the last exposure, the rats were sacrificed and the sperms collected. The caspase-3 activity was measured and sperm samples were morphological examined.
For the second experiment, 18 rats were divided into two groups: sham exposed group (male=3, female =6) and exposed group (male=3, female=6). After the exposure, rats of each group were mated. The number and the weight of the pups were regarded.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 900 MHz
Modulation type: pulsed
Exposure duration: continuous for 2 h/day for 45 days
  • power: 2 mW maximum
  • SAR: 0.9 W/kg maximum (manufacturer's data)
Exposure 1
Main characteristics
Frequency 900 MHz
Type
Exposure duration continuous for 2 h/day for 45 days
Modulation
Modulation type pulsed
Pulse width 0.577 ms
Repetition frequency 216.7 Hz
Additional info GSM mode
Exposure setup
Exposure source
Chamber rats placed individually in 18-22 cm long, 5.7 cm high and 4-7 cm wide Plexiglas cages, fixed with anechoic material and ventilated with 1 cm diameter holes; the cages were pasted with anechoic material on two sides of each box (top was not covered)
Setup mobile phone positioned on the top of the cage; mobility of the rats in the cage was limited to 1-2 cm; cell phones in silent mode without vibration
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
power 2 mW maximum measured - -
SAR 0.9 W/kg maximum - - manufacturer's data
Reference articles
Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated material:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

Spermatozoa from exposed rats showed significant morphological changes in midpiece region, microtubules, outer dense fibers of mitochondria and membranes and distortions in sperm head, compared to sham exposed rats. A statistically significant increase in activation of caspase-3 was observed in the sperm of exposed animals compared to sham exposed animals. Serum testosterone level was significantly decreased in exposed animals in comparison to sham exposed ones.
Exposed parents produced litters with a significantly decreased number of pups and the average body weight of the pups was significantly lower in comparison to those of sham exposed parents.
Study character:

Study funded by

  • Indian Council of Medical Research (ICMR), India

Related articles