研究のタイプ: 医学/生物学の研究 (experimental study)

[ラットの心血管系に対する50 Hz磁界の影響] med./bio.

The effects of a 50-Hz magnetic field on the cardiovascular system in rats.

掲載誌: J Radiat Res 2016; 57 (6): 627-636

この研究は、SDラットばく露群および擬似ばく露群:各n=64)に50Hz、100μTの磁界ばく露(または擬似ばく露)を1日20時間、24週間を与え、心血管系への影響を調べた。ばく露(または擬似ばく露)中、4週間に1回、血圧を測定した。24週間後に心エコー検査、心臓カテーテル検査、心電図検査を実施した後、心臓重量、体重を記録、組織検査などを行った。その結果、血圧心拍数とリズムにばく露群と擬似ばく露群との差はなかった;心エコーおよび心臓カテーテル検査による心臓の形態または血流動態にも差がなかった;心臓組織組織病理学的検査および心肥大関連遺伝子発現にも差がみられなかった、と報告している。

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研究目的(著者による)

The effects of chronic exposure of rats to a 50 Hz magnetic field on the cardiovascular system should be investigated.

詳細情報

Male rats were divided into 2 groups (n=64 each): 1) exposure to the magnetic field and 2) sham exposure.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 50 Hz
ばく露時間: intermittent 20 hours/day for 24 weeks

ばく露1

主たる特性
周波数 50 Hz
タイプ
  • magnetic field
ばく露時間 intermittent 20 hours/day for 24 weeks
ばく露装置
ばく露の発生源/構造
チャンバの詳細 polycarbonate ventilated cages (45 cm x 20 cm x 35 cm, L x W x H) with room temperature of 22-25°C and relative humidity of 45-55%
ばく露装置の詳細 exposure system consisted of an exposure device and a plastic rack, both made of acrylonitrile butadiene styrene plastic; the exposure device had five layers (200 cm x 100 cm x 200 cm, L x W x H) with a layer-to-layer distance of 35 cm; inside the exposure device, a plastic rack (140 cm x 70 cm x 200 cm, L x W x H) with four floors was placed; 24 plastic cages with 2-3 rats each were placed inside the system; bronze wires generated the uniform magnetic field; the wiring ratio of the five coils was 2:1:1:1:2 and the 3% uniformity area of each floor was 150 cm x 50 cm (L x W) and over the whole rack, uniformity was 5.2%; sound and temperature from the exposure system were close to those in the environment; exposure room was lacking other electric devices, e.g., computers and daylight lamps were kept far away from the system
Sham exposure A sham exposure was conducted.
Additional information currents in coils were in opposite directions in sham exposure system; exposure and sham exposure systems were located in separated and non-adjacent rooms with similar conditions
パラメータ
測定量 種別 Method Mass 備考
磁束密度 100 µT - 測定値 - -

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露前
  • ばく露中
  • ばく露後

研究の主なアウトカム(著者による)

No significant differences were found between the exposure and sham-exposure group.
The authors conclude that there were no effects of chronic exposure of rats to a 50 Hz magnetic field on the cardiovascular system.

研究の種別:

研究助成

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