研究のタイプ: 医学／生物学の研究 (experimental study)

[携帯電話からの電磁界はSDラットの内耳系に影響しない] med./bio.

Electromagnetic fields from mobile phones do not affect the inner auditory system of Sprague-Dawley rats

著者: Galloni P, Parazzini M, Piscitelli M, Pinto R, Lovisolo GA, Tognola G, Marino C, Ravazzani P
掲載誌: Radiat Res 2005; 164 (6): 798-804
RISフォーマットで参考文献をダウンロード

この研究は、GSM携帯電話の典型的な周波数（900および1800 MHz）の電磁界ばく露を受けたSprague-Dawleyラットの蝸牛機能を歪成分耳音響放射測定法で評価した。歪成分耳音響放射は、蝸牛の外有毛細胞の状態を表す指標としてよく知られている。48匹のラットをばく露群と擬似ばく露群に分けた。ばく露には 4つのループアンテナ１組を用い、ラットの耳への局所ばく露（局所SARは2 W / kg）を、2時間/日、5日/週、4週間継続した。歪成分耳音響放射測定は、ばく露前、ばく露中、ばく露後に行われた。その結果、ばく露群および擬似ばく露群で記録された聴覚信号の間に統計的に有意な差はなかった、と報告している。

The detailed summary of this article is not available in your language or incomplete. Would you like to see a complete translation of the summary? Then please contact us →

研究目的（著者による）

To evaluate the cochlear functionality of rats exposed to electromagnetic fields at the typical frequencies of GSM mobile phones (900 and 1800 MHz) by distortion product otoacoustic emissions.

詳細情報

The study is part of the GUARD project ("Potential Adverse Effects of GSM Cellular Phones on Hearing"), funded by the European Commission.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 900 MHz
Modulation type: pulsed
ばく露時間: repeated daily exposure, 2 h/day, 5 days/week for 4 weeks
  • SAR: 2 W/kg cf. remarks (local SAR in the cochlea)
ばく露2: 1,800 MHz
Modulation type: pulsed
ばく露時間: repeated daily exposure, 2 h/day, 5 days/week for 4 weeks
  • SAR: 2 W/kg cf. remarks (local SAR in the cochlea)

ばく露1

主たる特性
周波数 900 MHz
タイプ
  • electromagnetic field
特性
  • near field
ばく露時間 repeated daily exposure, 2 h/day, 5 days/week for 4 weeks
Modulation
Modulation type pulsed
Additional information

GSM modulation
ばく露装置
ばく露の発生源／構造
Distance between exposed object and exposure source 10 mm
チャンバの詳細 The exposure system for 12 rats consisted of three distinct arrays of four loop antennas printed on dielectric substrate, two for real and one for sham exposure (blinded). It was assembled in a wooden rack with RF-absorbing panels inserted between the arrays and on the four sides of the rack. Rats were placed close to a different antenna (in the same array) each day to obtain a uniform distribution of exposure.
ばく露装置の詳細 Animals were held in individual Perspex jigs with cylindrical tubes with a cone-shaped head end and a lockable piston in the tail end. Each antenna was held perpendicular to the head surface over the right ear of each rat in contact with the external side of the Perspex jig with a total distance from the cochlear system of about 8-10 mm.
Sham exposure A sham exposure was conducted.
パラメータ
測定量 値 種別 Method Mass 備考
SAR 2 W/kg cf. remarks 測定値および計算値 - local SAR in the cochlea
Additional parameter details

Fields at 50 Hz in the set-up were B = 0.05-0.08 µT and E = 0.7-1.7 V/m.

測定および計算の詳細

Numerical dosimetry was performed using a commercial FDTD code on a realistic model of the rat head with five fundamental tissues and a loop antenna positioned at 5 mm from the head surface. Measurements were performed using miniature probes on homogeneous phantoms and in the inner ear of a rat's cadaver using the power pulse method and a fluoroptic thermometer. Numerical and experimental dosimetry showed a good agreement.

ばく露2

主たる特性
周波数 1,800 MHz
タイプ
  • electromagnetic field
特性
  • near field
ばく露時間 repeated daily exposure, 2 h/day, 5 days/week for 4 weeks
Modulation
Modulation type pulsed
Additional information

GSM modulation
ばく露装置
ばく露の発生源／構造
  • E1と同じ装置
パラメータ
測定量 値 種別 Method Mass 備考
SAR 2 W/kg cf. remarks 測定値および計算値 - local SAR in the cochlea

Reference articles

  • Chou CK et al. (1999): [ハンドヘルド無線電話からのRF電磁界への人体ばく露を模擬したラット頭部ばく露システムの開発]

ばく露を受けた生物:

方法 影響評価項目／測定パラメータ／方法

研究対象とした生物試料:
研究対象とした臓器系:
  • 感覚器
  • ear
調査の時期:
  • ばく露前
  • ばく露中
  • ばく露後

研究の主なアウトカム（著者による）

The data showed no statistically significant differences between the audiological signals recorded for the different exposed and sham-exposed groups. There were no statistically significant changes in the outer hair cell functionality of rats exposed to electromagnetic fields at both GSM frequencies compared to the sham-exposed group.

研究の種別:

研究助成

関連論文