この研究は、900 MHzの電磁界へのばく露がSprague-Dawleyラットの蝸牛機能に与える影響を評価した。電磁界ばく露は、単独あるいはゲンタマイシンとの組み合わせばく露で実験を行い、蝸牛機能の評価には、蝸牛の外有毛細胞の状態を反映する指標である歪成分耳音響放射（DPOAE）を用いた。32匹のラットを4群に分けた。ゲンタマイシン投与群、ゲンタマイシン＋電磁界ばく露群、電磁界単独ばく露群、電磁界擬似ばく露群である。ゲンタマイシン投与は、150 mg / kg体重の筋肉内注射を15日間毎日行った。電磁界は、ラット耳での局所SARが4 W / kgの900 MHzの連続波で、2時間/日、5日/週、4週間ばく露した。ばく露の前、最中および後にDPOAE試験を実施した。その結果、正常な耳または既知の病理学的因子（ゲンタマイシン）ばく露を受けた耳のいずれにおいても、電磁界への亜慢性ばく露がラットの内耳聴覚機能に影響することは示されなかった、と報告している。
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To evaluate the cochlear functionality of rats exposed to electromagnetic fields at 900 MHz and to gentamicin (loss of hearing or balance is a well-documented adverse effect of such aminoglycoside antibiotics).
32 rats were divided into four groups: group 1 was treated with daily intramuscular injections of gentamicin for 15 days (150 mg/kg); group 2 was treated with daily intramuscular injections of gentamicin for 15 days (same dose) and exposed to electromagnetic fields; group 3 was exposed to electromagnetic fields; group 4 was sham-exposed.
Modulation type: CW
ばく露時間: repeated daily exposure, 2 h/day, 5 days/week, for 4 weeks
|ばく露時間||repeated daily exposure, 2 h/day, 5 days/week, for 4 weeks|
|Distance between exposed object and exposure source||10 mm|
|チャンバの詳細||The exposure system consisting of three distinct arrays of four loop antennas to expose 12 rats simultaneously was assembled in a wooden rack with RF absorbing panels on the four sides and between the levels [Galloni et al., 2005]. The arrays were used simultaneously, two for real and one for sham exposure, and were connected (blinded) to the MW generator through a black box.|
|ばく露装置の詳細||Rats were individually restrained in cylindrical Perspex tubes with a cone-shaped head end. The antenna was held in contact with the tube perpendicular to the head surface over the right ear of the rat at a total distance of about 8-10 mm from the cochlea (localised exposure).|
|Sham exposure||A sham exposure was conducted.|
|Additional information||Rats were placed close to a different antenna (in the same array) each day to ensure a uniform distribution of exposure. The antennas were rectangular loops printed on dielectric substrate using the coplanar line technique [Leveque et al., 2004].|
The data showed no evidence of a combined effect of a radiofrequency electromagnetic field exposure and gentamicin on the auditory system of rats under these experimental conditions.