研究のタイプ: 医学/生物学の研究 (experimental study)

[ラットにおける幾つかの生理学的及び生化学的パラメータに対するGSM周波数電磁界放射の影響] med./bio.

Effects of GSM-Frequency Electromagnetic Radiation on Some Physiological and Biochemical Parameters in Rats.

掲載誌: Bull Exp Biol Med 2012; 153 (6): 816-819

この研究は、非近交系のラット(雌雄各10匹)をばく露群および擬似ばく露群に分け、単回の905 MHz 電磁界ばく露(2時間、プラスティック容器に固定)を行い、オープンフィールドテストによる行動の観察と血液検査を、ばく露擬似ばく露)終了の5分後(急性影響)と24時間後(遅発性影響)に行った。その結果、ばく露群の雌では不安の増大、運動性・方向反応・探索行動の低下が、雄では方向反応・探索行動の低下が見られた;血漿中コルチコイド濃度と抗酸化系活性が雌雄とも上昇した;雌雄共に急性影響に加えて、24時間後に遅発性影響も観察された、などを報告している。

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研究目的(著者による)

To investigate the main behavioral patterns and biochemical stress parameters in rats exposed to a GSM signal.

詳細情報

In the first experiment, acute and delayed effects of a GSM signal on behavioral pattern were examined. Therefore, 4 groups of male rats and 4 groups of female rats were investigated: 1.) 5 min after sham exposure, 2.) 5 min after exposure, 3.) 24 h after sham exposure and 4.) 24 h after exposure.
In the second experiment, acute (20 min) and delayed (24 h) effects of a GSM signal on the antioxidant defense system and on oxidative stress parameters were examined. Again, 4 male and 4 female groups (see above) were used.
Each group contained 10 rats.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 905 MHz
Modulation type: pulsed
ばく露時間: continuous for 2 h

ばく露1

主たる特性
周波数 905 MHz
タイプ
  • electromagnetic field
ばく露時間 continuous for 2 h
Modulation
Modulation type pulsed
Additional information

GSM in discontinuous transmission mode

ばく露装置
ばく露の発生源/構造
  • セルラ-電話
  • Ericsson GF337
ばく露装置の詳細 animals placed in a plastic container
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
電力 2 W - - - -
SAR 1.67 W/kg - - whole body -

Reference articles

  • Belyaev IY et al. (2006): [915 MHzGSMマイクロ波へのラット脳のばく露は、遺伝子発現変化を誘導するが、二重鎖EDNAブレークまたはクロマチン形成への効果はない].

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

In the open field test, 5 minutes after exposure, male rats from the exposed group showed an increased vertical motor activity and more center visits compared to sham exposed males. On the contrary, exposed female rats showed a decreased horizontal and vertical motor activity, as well as less center visits, while the freezing time and the number of defecations was increased compared to sham exposed females. 24 hours after the exposure, exposed male rats showed less center visits than sham exposed males, while exposed females showed an increased number of defecations and an elongated freezing time compared with the sham exposed group.
Analysis of plasma levels of glucocorticoids revealed an increase 20 minutes after the exposure in male and female exposed rats compared to sham exposed ones, while the delayed effects (24 hours after exposure) were only seen in male exposed rats (decreased glucocorticoid levels).
Evaluation of the effects of exposure on the antioxidant defense system showed that the levels of lipid hydroperoxides decreased in male rats 20 minutes after exposure in comparison to the control. In exposed females, increased superoxide dismutase-like activity was detected 24 hours after exposure. No changes in other parameters of the antioxidant defense system occurred.
The authors suggest that a single exposure to a GSM signal with a frequency of 905 MHz could have an influence on locomotor, orientation and exploratory activities and anxiety of rats, as well as on the antioxidant defense system. Some of the observed effects could depend on animal gender.

研究の種別:

研究助成

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