研究のタイプ: 医学/生物学の研究 (experimental study)

[無線周波放射にばく露されたヒト血液リンパ球での適応応答の誘導] med./bio.

Induction of adaptive response in human blood lymphocytes exposed to radiofrequency radiation.

掲載誌: Radiat Res 2009; 171 (6): 735-742

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研究目的(著者による)

To study whether non-ionizing radiofrequency exposure, given as an adaptation dose for 20 h, renders the cells refractory to the genetic damage induced by a subsequent challenge dose with the genotoxic agent mitomycin C.

詳細情報

Adaptive response: Different cell types that were exposed to an extremely small adaptation dose of a genotoxic agent were found to be less susceptible to the induction of genetic damage when given a higher challenge dose of the same or similar genotoxic agent. The induction of an adaptive response was shown to be influenced by several factors (e.g. the dose used for adaptation, the dose rate, the time between the adaptation and challenge doses).
Lymphocytes of five different donors were investigated.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 900 MHz
ばく露時間: continuous for 20 h
  • SAR: 10 W/kg peak
  • SAR: 1.25 W/kg average over mass

ばく露1

主たる特性
周波数 900 MHz
タイプ
  • electromagnetic field
ばく露時間 continuous for 20 h
ばく露装置
ばく露の発生源/構造
  • wire patch cell
ばく露装置の詳細 wire patch cell shielded by a metal grid box, placed inside an incubator
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
SAR 10 W/kg peak 測定値および計算値 - -
SAR 1.25 W/kg average over mass 測定値および計算値 - -

Reference articles

  • Palumbo R et al. (2008): [900 MHz無線周波放射へのばく露は増殖活動中のヒトリンパ球にカスパーゼ3活性化を誘導する]
  • Scarfi MR et al. (2006): [ラジオ周波数照射(900 MHz, GMSシグナル)はヒト末梢血リンパ球での微少核形成頻度ならびに細胞増殖に影響しない:実験室間研究]

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

Lymphocytes of four donors exhibited the induction of an adaptive response. Cells that were pre-exposed to 900 MHz radiofrequency irradiation had a significantly decreased incidence of micronuclei induced by the challenge dose of mitomycin C compared to those that were not pre-exposed to 900 MHz radiofrequency irradiation. However, induction of the adaptive response was not observed in the remaining fifth donor. The incidence of micronuclei induced by the challenge dose of mitomycin C was not significantly different between the pre-exposed and unexposed lymphocytes.
In conclusion, the data obtained in this preliminary investigation indicated that radiofrequency exposure at a frequency in use for wireless communications are capable of inducing an adaptive response in human blood lymphocytes. Further research is needed regarding whether an adaptive response can be elicited in other in vitro and in vivo experimental conditions (including various frequencies, different SAR values, timing of adaptation etc.).

研究の種別:

研究助成

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