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To study the radioprotective effect of bee venom against DNA damage induced by 915 MHz microwave irradiation in rat lymphocytes.
Honeybee venom is a complex mixture of different active components including peptides, enzymes and amines which have a variety of pharmaceutical properties. Bee venom is used in traditional medicine to treat a variety of diseases (e.g. arthritis, rheumatism, back pain) and it has been reported that it possess anti-mutagenic, pro-inflammatory, anti-inflammatory, anti-nociceptive and anti-cancer effects. Additionally it has been reported to possess a radioprotective capacity against gamma radiation.
Whole blood lymphocytes of Wistar rats are treated with 1 µg/ml bee venom four hours prior to and immediately before irradiation.
|ばく露時間||continuous for 30 min|
GSM basic signal modulation
|ばく露装置の詳細||blood placed inside a certified gigahertz transversal electromagnetic mode cell|
The standard comet assay revealed that microwave exposure increased the DNA damage in rat lymphocytes.
The Fpg-modified comet assay (as marker for oxidative stress induced DNA damage) revealed statistical differences compared to controls, suggesting that oxidative stress is a possible mechanism of DNA damage induction.
The data showed that bee venom has a radioprotective effect against basal and oxidative DNA damage. Bee venom alone (at a concentration of 1 µg/ml) did not have any impact on genotoxicity and did not produce oxidative damage in rat lymphocytes.