研究のタイプ: 医学/生物学の研究 (experimental study)

[イン・ビトロのヒトリンパ球に対する18.0および16.5GHzマイクロ波放射の細胞遺伝学的影響] med./bio.

Cytogenetic effects of 18.0 and 16.5 GHz microwave radiation on human lymphocytes in vitro.

掲載誌: Anticancer Res 2009; 29 (8): 2885-2892

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研究目的(著者による)

To study the cytogenetic effects of microwave irradiation alone or in combination with mitomycin C (co-exposure) in human lymphocytes.

詳細情報

Lymphocytes from two smoking and four non-smoking donors were exposed for 53 hours to continuous wave irradiation at 18.0 GHz or to pulsed wave at 16.5 GHz, alone or in combination with mitomycin C. In some cell cultures DNA synthesis (hydroxyurea) and DNA repair (caffeine) were inhibited.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 18 GHz
Modulation type: CW
ばく露時間: continuous for 53 hr
ばく露2: 16.5 GHz
Modulation type: pulsed
ばく露時間: continuous for 53 hr

General information

cells were treated i) with RF exposure only ii) with RF exposure and mitomycin C after 30 hr of exposure

ばく露1

主たる特性
周波数 18 GHz
タイプ
  • electromagnetic field
特性
  • far field
ばく露時間 continuous for 53 hr
Modulation
Modulation type CW
ばく露装置
ばく露の発生源/構造
ばく露装置の詳細 5 m x 4 m x 4 m anechoic chamber with constant temperature and the horn antenna placed under the samples
パラメータ
測定量 種別 Method Mass 備考
電界強度 19 V/m effective value 測定値 - -
電力密度 1 W/m² average over time 測定値 - -

ばく露2

主たる特性
周波数 16.5 GHz
タイプ
  • electromagnetic field
特性
  • far field
ばく露時間 continuous for 53 hr
Modulation
Modulation type pulsed
Duty cycle 50 %
Repetition frequency 1 kHz
ばく露装置
ばく露の発生源/構造
Distance between exposed object and exposure source 1.2 m
ばく露装置の詳細 two rectangular horn antennas placed under the 5 m x 4 m x 4 m anechoic chamber with constant temperature
パラメータ
測定量 種別 Method Mass 備考
電力密度 10 W/m² average over time 測定値 - -

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

No synergistic effect was observed in cells co-exposed to microwave irradiation and mitomycin C, or to cells pre-exposed in vivo to tobacco smoke. For the 16.5 GHz pulsed microwave exposure, a non-significant trend consisting of an increase in chromosome aberration frequencies with microwave irradiation was shown for the DNA synthesis and DNA repair inhibited cultures both with and without mitomycin C.
The authors conclude, that neither 18.0 GHz continuous wave nor 16.5 GHz pulsed wave exposure of human lymphocytes induced statistically significant increases in chromosome aberration frequencies. 16.5 GHz pulsed wave exposure requires further studies before a true negative conclusion can be drawn.

研究の種別:

研究助成

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