研究のタイプ: 医学/生物学の研究 (experimental study)

[マウス扁平上皮がん培養細胞AT478での抗酸化メラトニン特性に対する超低周波磁界の影響] med./bio.

Influence of extremely-low-frequency magnetic field on antioxidative melatonin properties in AT478 murine squamous cell carcinoma culture.

掲載誌: Biol Trace Elem Res 2004; 102 (1-3): 227-243

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研究目的(著者による)

To study the effects of extremely low frequency electromagnetic fields and antioxidant supplementation (melatonin, 10-3, 10-4 and 10-5 M; 24 h or 72 h), alone or in combination, on antioxidant enzyme activities and on the level of lipid peroxidation in a carcinoma cell line in vitro.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 3 Hz–3 kHz
ばく露時間: continuous for 16 min

ばく露1

主たる特性
周波数 3 Hz–3 kHz
タイプ
  • magnetic field
ばく露時間 continuous for 16 min
ばく露装置
ばく露の発生源/構造
  • medical magnetostimulation device MRS-2000
パラメータ
測定量 種別 Method Mass 備考
磁束密度 0.11 mT effective value 測定値 - -

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

After melatonin treatment alone, antioxidative enzyme activities were increased and the malondialdehyde level was decreased.
Exposure to extremely low frequency magnetic field alone caused an increase of both superoxide dismutase enzyme activities and malondialdehyde level, but the influence on glutathione peroxidase enzyme activity was negligible.
All enzyme activities in culture medium containing melatonin (all concentrations) were significantly diminished after exposure to extremely low frequency magnetic field compared to cells treated with melatonin alone. Also malondialdehyde levels were significantly decreased after co-exposure to melatonin and extremely low frequency magnetic field.
The authors conclude that the data suggest that extremely low frequency magnetic field attenuates antioxidative actions of melatonin on cellular level.

研究の種別:

研究助成

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