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To study the effect of 2.45 GHz electromagnetic irradiation on the oxidant and antioxidant status in the skin of rats and to examine the possible protective effects of beta-glucan against the oxidative damage.
32 male rats were randomly divided into four equal groups: 1) cage control, 2) sham exposed group, 3) exposure group and 4) exposure + beta-glucan treatment (50 mg/kg/day before each exposure).
|ばく露時間||continuous for 60 min/day during 4 weeks|
|Repetition frequency||217 Hz|
|ばく露装置の詳細||rat placed in a 15 cm long PVC-cylinder with a diameter of 5 cm; 6 cylinders positioned radially on a round Plexiglas base plate so that the rats' noses were in close contact to the antenna which was placed in the center of the plate; cylinders ventilated; exposure system kept in a Faraday cage with a shielding effectiveness of 80 dB|
|Sham exposure||A sham exposure was conducted.|
Exposure to 2.45 GHz irradiation caused a significant increase in malondialdehyde levels and catalase enzyme activity, while the enzyme activities of superoxide dismutase and glutathione peroxidase decreased, compared with the cage control or sham exposed group.
Beta-glucan administration significantly reversed the elevation of malondialdehyde levels and the reduction of superoxide dismutase enzyme activity. Beta-glucan treatment also slightly, but not statistically significantly enhanced the activity of catalase and prevented the decrease of glutathione peroxidase enzyme activity caused by electromagnetic field exposure.
The data demonstrated the role of oxidative mechanisms in electromagnetic field-induced skin tissue damages and that beta-glucan could ameliorate oxidative skin injury via its antioxidant properties.