研究のタイプ: 医学／生物学の研究 (experimental study)

[ラット皮膚組織に2.45GHz電磁放射が誘導する酸化的損傷に対するβ-グルカンの保護作用] med./bio.

Protective effects of beta-glucan against oxidative injury induced by 2.45-GHz electromagnetic radiation in the skin tissue of rats.

著者: Ceyhan AM, Akkaya VB, Gulecol SC, Ceyhan BM, Ozguner F, Chen W
掲載誌: Arch Dermatol Res 2012; 304 (7): 521-527
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研究目的（著者による）

To study the effect of 2.45 GHz electromagnetic irradiation on the oxidant and antioxidant status in the skin of rats and to examine the possible protective effects of beta-glucan against the oxidative damage.

詳細情報

32 male rats were randomly divided into four equal groups: 1) cage control, 2) sham exposed group, 3) exposure group and 4) exposure + beta-glucan treatment (50 mg/kg/day before each exposure).

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 2.45 GHz
Modulation type: pulsed
ばく露時間: continuous for 60 min/day during 4 weeks

General information

Rats were treated in the following four groups: i) cage control ii) sham exposure iii) EMF exposure iv) EMF exposure + treatment with β-glucan

ばく露1

主たる特性
周波数 2.45 GHz
タイプ
  • electromagnetic field
ばく露時間 continuous for 60 min/day during 4 weeks
Modulation
Modulation type pulsed
Repetition frequency 217 Hz
ばく露装置
ばく露の発生源／構造
  • half-wave dipole antenna
ばく露装置の詳細 rat placed in a 15 cm long PVC-cylinder with a diameter of 5 cm; 6 cylinders positioned radially on a round Plexiglas base plate so that the rats' noses were in close contact to the antenna which was placed in the center of the plate; cylinders ventilated; exposure system kept in a Faraday cage with a shielding effectiveness of 80 dB
Sham exposure A sham exposure was conducted.
パラメータ
測定量 値 種別 Method Mass 備考
電力 2 W maximum - - -
電界強度 25 V/m average over mass 測定値 - -
電界強度 70 V/m maximum 測定値 - at the animal's nose
SAR 64 mW/kg average over mass 計算値 - -
SAR 1 W/kg maximum 計算値 partial body -

Reference articles

  • Naziroglu M et al. (2009): [ラットの脳内における無線機器（2.45 GHz）由来の酸化ストレス及び脳電図記録にL-カルニチン及びセレンが及ぼす変調作用]

ばく露を受けた生物:

方法 影響評価項目／測定パラメータ／方法

研究対象とした生物試料:
研究対象とした臓器系:
  • 感覚器
  • skin
調査の時期:
  • ばく露後

研究の主なアウトカム（著者による）

Exposure to 2.45 GHz irradiation caused a significant increase in malondialdehyde levels and catalase enzyme activity, while the enzyme activities of superoxide dismutase and glutathione peroxidase decreased, compared with the cage control or sham exposed group.
Beta-glucan administration significantly reversed the elevation of malondialdehyde levels and the reduction of superoxide dismutase enzyme activity. Beta-glucan treatment also slightly, but not statistically significantly enhanced the activity of catalase and prevented the decrease of glutathione peroxidase enzyme activity caused by electromagnetic field exposure.
The data demonstrated the role of oxidative mechanisms in electromagnetic field-induced skin tissue damages and that beta-glucan could ameliorate oxidative skin injury via its antioxidant properties.

研究の種別:

研究助成

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