この論文は、無線装置の電磁界（EMR）がフリーラジカルを増加させることにより生物に影響を与えるかも知れないという仮説を検証するために、30匹のラットを6匹ずつ、5群（ケージコントロール群、擬似ばく露群、2.45GHzEMRばく露群、EMR+セレニウム投与群、EMR+Lカルニチン投与群）に分け、2.45GHzEMRばく露は1日60分、28日間ばく露し、実験後に各群の心電図記録と大脳皮質標本を比較した。Lカルニチンとセレニウムは抗酸化物質の酸化還元系をサポートすることにより、EMRがもたらすビタミン低下に対する防御作用を持つように見えたと結論している。
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To investigate the effects of 2.45 GHz exposure on the brain antioxidant redox system and EEG in rats, as well as protective effects of selenium and L-carnitine on brain oxidative injury induced by electromagnetic exposure.
Selenium is an essential trace element which plays an important role in a number of biological processes. L-carnitine is an essential co-factor in the metabolism of lipids and in the production of cellular energy.
30 male rats were divided into five groups: 1) cage control; 2) sham exposure; 3) 2.45 GHz exposure; 4) 2.45 GHz exposure + selenium; 5) 2.45 GHz exposure + L-carnitine. The first dose of selenium and L-carnitine was administered 24 h before exposure. Before sacrificing the animals EEG recordings were taken.
animals were divided into five groups: i) cage control ii)sham control iii) exposure to EMF iv) exposure to EMF + selenium v) exposure to EMF + L-carnitine
| 周波数 | 2.45 GHz |
|---|---|
| タイプ |
|
| ばく露時間 | continuous for 60 min/day, for 28 days |
| Modulation type | pulsed |
|---|---|
| Repetition frequency | 217 Hz |
| ばく露の発生源／構造 |
|
|---|---|
| ばく露装置の詳細 | rats kept in 15 cm long cylindrical constrainers with a diameter of 5 cm so that the rats' noses were in close contact with the antenna; exposure system positioned inside a faraday cage |
| Sham exposure | A sham exposure was conducted. |
The concentrations of the antioxidant vitamin A, vitamin C and vitamin E were significantly lower in the exposure group (3) than in the control groups (1, 2). The groups 4 and 5 had significantly higher vitamin concentrations than the exposure group (3). Regarding the mean glutathione level, glutathione peroxidase enzyme activity and ß-carotene values, no significant differences between the five groups were observed. Only in group 4 the glutathione peroxidase enzyme acitivity was significantly higher than in group 1. Lipid peroxidation was significantly lower in group 4 and 5 compared to group 1, 2 and 3, indicating an effect of selenium and L-carnitine. However, lipid peroxidation was not affected by 2.45 GHz exposure compared to the control groups (1, 2).
During the EEG recordings, the 2.45 GHz exposure did not affect spike numbers, but in group 4 and 5 they were significantly decreased compared to the exposure group (3).
L-carnithine and selenium seemed to have protective effects on the 2.45 GHz induced decrease of vitamins. The L-carnitine administration seemed to be more protective than the selenium administration.
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