研究のタイプ: 医学/生物学の研究 (experimental study)

[ラットの脳内における無線機器(2.45 GHz)由来の酸化ストレス及び脳電図記録にL-カルニチン及びセレンが及ぼす変調作用] med./bio.

Modulator effects of L-carnitine and selenium on wireless devices (2.45 GHz)-induced oxidative stress and electroencephalography records in brain of rat.

掲載誌: Int J Radiat Biol 2009; 85 (8): 680-689

この論文は、無線装置の電磁界(EMR)がフリーラジカルを増加させることにより生物に影響を与えるかも知れないという仮説を検証するために、30匹のラットを6匹ずつ、5群(ケージコントロール群、擬似ばく露群、2.45GHzEMRばく露群、EMR+セレニウム投与群、EMR+Lカルニチン投与群)に分け、2.45GHzEMRばく露は1日60分、28日間ばく露し、実験後に各群の心電図記録と大脳皮質標本を比較した。Lカルニチンとセレニウムは抗酸化物質酸化還元系をサポートすることにより、EMRがもたらすビタミン低下に対する防御作用を持つように見えたと結論している。

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研究目的(著者による)

To investigate the effects of 2.45 GHz exposure on the brain antioxidant redox system and EEG in rats, as well as protective effects of selenium and L-carnitine on brain oxidative injury induced by electromagnetic exposure.

詳細情報

Selenium is an essential trace element which plays an important role in a number of biological processes. L-carnitine is an essential co-factor in the metabolism of lipids and in the production of cellular energy.
30 male rats were divided into five groups: 1) cage control; 2) sham exposure; 3) 2.45 GHz exposure; 4) 2.45 GHz exposure + selenium; 5) 2.45 GHz exposure + L-carnitine. The first dose of selenium and L-carnitine was administered 24 h before exposure. Before sacrificing the animals EEG recordings were taken.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 2.45 GHz
Modulation type: pulsed
ばく露時間: continuous for 60 min/day, for 28 days
  • 電力: 2 W maximum
  • SAR: 0.1 W/kg average over mass (whole body)
  • SAR: 1.73 W/kg average over mass (brain)

General information

animals were divided into five groups: i) cage control ii)sham control iii) exposure to EMF iv) exposure to EMF + selenium v) exposure to EMF + L-carnitine

ばく露1

主たる特性
周波数 2.45 GHz
タイプ
  • electromagnetic field
ばく露時間 continuous for 60 min/day, for 28 days
Modulation
Modulation type pulsed
Repetition frequency 217 Hz
ばく露装置
ばく露の発生源/構造
  • half-wave antenna
ばく露装置の詳細 rats kept in 15 cm long cylindrical constrainers with a diameter of 5 cm so that the rats' noses were in close contact with the antenna; exposure system positioned inside a faraday cage
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
電力 2 W maximum - - -
SAR 0.1 W/kg average over mass - whole body -
SAR 1.73 W/kg average over mass 計算値 brain -

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露前
  • ばく露中
  • ばく露後

研究の主なアウトカム(著者による)

The concentrations of the antioxidant vitamin A, vitamin C and vitamin E were significantly lower in the exposure group (3) than in the control groups (1, 2). The groups 4 and 5 had significantly higher vitamin concentrations than the exposure group (3). Regarding the mean glutathione level, glutathione peroxidase enzyme activity and ß-carotene values, no significant differences between the five groups were observed. Only in group 4 the glutathione peroxidase enzyme acitivity was significantly higher than in group 1. Lipid peroxidation was significantly lower in group 4 and 5 compared to group 1, 2 and 3, indicating an effect of selenium and L-carnitine. However, lipid peroxidation was not affected by 2.45 GHz exposure compared to the control groups (1, 2).
During the EEG recordings, the 2.45 GHz exposure did not affect spike numbers, but in group 4 and 5 they were significantly decreased compared to the exposure group (3).
L-carnithine and selenium seemed to have protective effects on the 2.45 GHz induced decrease of vitamins. The L-carnitine administration seemed to be more protective than the selenium administration.

研究の種別:

研究助成

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