研究のタイプ: 医学/生物学の研究 (experimental study)

[ヒトTリンパ球とラット初期アストロサイトでのラジオ周波数照射はストレス反応を誘導しない] med./bio.

Radiofrequency radiation does not induce stress response in human T-lymphocytes and rat primary astrocytes.

掲載誌: Bioelectromagnetics 2006; 27 (7): 578-588

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研究目的(著者による)

To study the effects of 1763 MHz irradiation emitted from mobile phones on stress response.

詳細情報

Expression of heat shock proteins and the phosphorylation of the mitogen-activated protein kinases (MAPK; major participants in stress responses) were monitored. Whether radiofrequency exposure exerted a synergistic effect on the status of mitogen-activated protein kinase phosphorylation induced by TPA was also determined. Positive controls were performed (43°C, 30 min).

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 1,762.5 MHz
ばく露時間: continuous for 30 min or 1 h
  • SAR: 2 W/kg mean
  • SAR: 20 W/kg mean

ばく露1

主たる特性
周波数 1,762.5 MHz
タイプ
  • electromagnetic field
特性
  • guided field
ばく露時間 continuous for 30 min or 1 h
Modulation
Modulation type cf. additional information
Additional information

CDMA signal

ばく露装置
ばく露の発生源/構造
チャンバの詳細 The experimental chamber (W 115 mm x H 80 mm x L 240 mm) was made of aluminium and therefore shielded. The temperature was maintained at 37 ± 0.2°C by cooling water circulating through its bottom. Gas from an incubator was circulated through the cavity to maintain CO2 density and humidity.
ばく露装置の詳細 The RF signal was fed by a λ/8 monopole antenna (22 mm long) at the λ/4 position of the top plate of the cavity exciting only the fundamental TE102 mode and allowing a uniform exposure of a 100-mm culture dish. The 100-mm Petri dish having an inner diameter of 85 mm, a 1-mm wall, and a 91-mm lid was filled with 18 ml of culture medium standing 4 mm high.
Sham exposure A sham exposure was conducted.
Additional information For positive (heat shock) control, culture dishes were wrapped tightly with parafilm and immersed in a water bath at 43 ± 0.2°C for 30 min.
パラメータ
測定量 種別 Method Mass 備考
SAR 2 W/kg mean 測定値および計算値 - -
SAR 20 W/kg mean 測定値および計算値 - -

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

No detectable difference was found in the expression levels of the different heat shock proteins of exposed cells as compared to the levels measured in sham-exposed cells. The phosphorylation status of mitogen-activated protein kinases, extracellular signal-regulated kinases, c-Jun N-terminal protein kinases, or p38, did not change significantly.
When TPA alone was applied, the mitogen-activated protein kinases were found to be phosphorylated in a dose-dependent manner. However, radiofrequency irradiation did not result in any enhancement of TPA-induced phosphorylation. Neither TPA nor radiofrequency irradiation exerted any detectable effect on the induction of heat shock proteins.

研究の種別:

研究助成

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