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The effects of exposure of neuroblastoma cells to a 2.1 GHz electromagnetic field (W-CDMA) on apoptosis and cell cycle progression should be investigated.
Neuroblastoma cells were used as a in vitro model for neural cells in embryos and infants, as it is assumed that these developmental stages are more sensitive to electromagnetic fields than adults.
|ばく露時間||continuous for 24 hours|
|Modulation type||cf. additional information|
|チャンバの詳細||polystyrene plate with 24 wells in a CO2 incubator|
|ばく露装置の詳細||antenna which radiated vertically upwards on the well plate 1 mm above; the temperature inside the incubator was kept constant at 37°C|
|Sham exposure||A sham exposure was conducted.|
The gene expressions of c-myc and cyclin D1 were significantly decreased and the percentage of cells in G1 phase was significantly higher in exposed cells compared to sham exposed cells, indicating cell cycle arrest in G1 phase.
There were no significant differences in apoptosis, cell viability or DNA fragmentation observed between exposed and sham exposed cells.
The authors conclude that exposure of neuroblastoma cells to a 2.1 GHz electromagnetic field (W-CDMA) has no effect on apoptosis but might change the cell cycle progression.