研究のタイプ: 医学/生物学の研究 (experimental study)

[携帯電話基地局による酸化ストレスに対するゴマ油の保護的役割] med./bio.

Protective role of sesame oil against mobile base station-induced oxidative stress.

掲載誌: J Radiat Res Appl Sci 2014; 7 (1): 1-6

この研究は、ラットに、携帯電話基地局(実験室のある建物に設置された)からの電磁放射(EMR:900 MHzアンテナラットのケージとの距離は8m、電力密度測定値は0.5 mW/ cm2)への慢性ばく露(24時間/日、8週間)を与え、血液パラメータへの影響を調べ、その影響に対するゴマ油の保護作用も合わせて調べた。雄アルビノラットを、対照群と3つのばく露群(各n = 8)に分け、3つのばく露群にはそれぞれ、ゴマ油を0、1.5、3 ml経口摂取させた(週に3回)。慢性ばく露終了後に、血漿中のグルタチオンレダクターゼ(GSH-Rx)、スーパーオキシドジスムターゼ(SOD)、カタラーゼ(CAT)、総テストステロンおよび脂質プロファイル(総コレステロール(Tch)、トリグリセリド(TG)、低密度リポタンパクコレステロール(LDL-c)および高密度リポタンパクコレステロール(HDL-c))を測定した。その結果、3つのばく露群で、対照群に比べ、TGとテストテロンが有意に上昇し、かつゴマ油の摂取量依存的に有意に上昇した;SODおよびCAT活性は、対照群に比べ、EMRのみのばく露群では有意に低下したが、EMR +ゴマ油摂取群では油の摂取量依存的に有意に上昇した;3mlのゴマ油摂取群でのみ、総コレステロールの顕著な低下、GSH-Rxの有意な上昇が見られた、と報告している。

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研究目的(著者による)

The effects of exposure of rats to a 900 MHz electromagnetic field on blood parameters and the possible protective role of sesame oil (antioxidant) against oxidative stress should be investigated.

詳細情報

Rats were divided into the following groups (n=8 each): 1) exposure to the electromagnetic field, 2) exposure and administration of 1.5 ml sesame oil, 3) exposure and administration of 3 ml sesame oil, 4) control group. Groups 2 and 3 received the sesame oil orally three times a week.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 900 MHz
ばく露時間: continuous for 24 h/day for 8 weeks

ばく露1

主たる特性
周波数 900 MHz
タイプ
  • electromagnetic field
ばく露時間 continuous for 24 h/day for 8 weeks
ばく露装置
ばく露の発生源/構造
  • 基地トランシーバ局
Distance between exposed object and exposure source 8 m
チャンバの詳細 plastic cages
ばく露装置の詳細 base station was constructed on the roof of a building
パラメータ
測定量 種別 Method Mass 備考
電力密度 0.5 mW/cm² - 測定値 - -

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

The level of testosterone was significantly increased in all exposure groups (groups 1-3) and the level of triglycerides was significantly increased in both exposure groups with sesame oil (groups 2 and 3) compared to the control group.
The superoxide dismutase and catalase enzyme activities were significantly reduced in exposed rats without sesame oil (group 1) and they were significantly increased in exposed rats with sesame oil (partly in group 2, consistently in group 3) compared to the control group.
The total cholesterol level was significantly reduced and the glutathione reductase enzyme activity was significantly increased in group 3 compared to the control group.
HDL and LDL cholesterol showed contrary trends: HDL cholesterol was significantly reduced in group 1 compared to the control group and groups 2 and 3 showed significantly increased values compared to group 1. LDL cholesterol was significantly increased in group 1 compared to the control group and groups 2 and 3 showed significantly reduced values compared to group 1.
The authors conclude that exposure of rats to a 900 MHz electromagnetic field might influence blood parameters and induce oxidative stress and that sesame oil as an antioxidant might attenuate these effects.

研究の種別:

研究助成

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