この研究は、オランダの人口ベースの大規模な前向きコホート研究において、6種類の職業ばく露(殺虫剤、有機溶剤、金属、ジーゼル車排気ガス、超低周波磁界(ELF-MF)、電撃)とパーキンソン病(PD)による死亡との関連を調査した。この調査の母体であるコホート調査は、1986年に55-69歳であった男性58276人、女性62573人を取り込み、2003年まで17.3年間、死因別の死亡率を追跡し、PDによる死亡(男性402人、女性207人)を確認した。このコホートから5000人を無作為に抽出したサブコホートにおいて、症例−コホートの研究デザインで、PD死亡と各種職業ばく露との関連をCox回帰分析により評価した。職業ばく露評価は、職種ばく露マトリクスに基づいた。その結果、男性で、殺虫剤およびELF-MFへの過去のばく露が高かった群においてハザード比の上昇が見られたが、ばく露期間との関連や累積ばく露における傾向性は何も見られなかった;女性では、高ばく露群の数が少ないため結果は不安定であった、と報告している。
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The association between the occupational exposure to extremely low-frequency magnetic fields, electrical shocks as well as other risk factors and the risk of Parkinson disease mortality was investigated in the Netherlands Cohort Study. Furthermore, the effects of combined exposure to these occupational risk factors were studied.
Following a case-cohort approach, a randomly selected subcohort (n=5000) was drawn.
グループ | 説明 |
---|---|
参照集団 1 | magnetic field exposure: background |
集団 2 | magnetic field exposure: low |
集団 3 | magnetic field exposure: high |
参照集団 4 | cumulative exposure: background |
集団 5 | cumulative exposure: 1st terzile |
集団 6 | cumulative exposure: 2nd terzile |
集団 7 | cumulative exposure: 3rd terzile |
参照集団 8 | electric shock risk: background |
集団 9 | electric shock risk: low |
集団 10 | electric shock risk: high |
参照集団 11 | electric shock; cumulative exposure: 1st terzile |
集団 12 | electric shock; cumulative exposure: 2nd terzile |
集団 13 | electric shock; cumulative exposure: 3rd terzile |
タイプ | 値 |
---|---|
合計 | 120,852 |
17.3 years of follow-up
Among men, an elevated hazard ratio was observed for high exposure to occupational extremely low-frequency magnetic fields (HR 1.54, CI 1.00-2.36) but neither association with exposure duration nor a trend in cumulative exposure were observed. No association between Parkinson disease mortality and occupational exposure to electric shocks was found. No significant associations between Parkinson disease mortality and occupational exposure to extremely low-frequency magnetic fields as well as electric shocks were observed among women.
When the analysis of exposure to extremely low-frequency magnetic fields was adjusted for risk of electric shocks, the association between high exposure to extremely low-frequency magnetic fields and Parkinson disease mortality became stronger (HR 1.81, CI 1.15-2.85). This suggests that, if the observed association between high exposure to extremely low-frequency magnetic fields and Parkinson disease risk is true, this is likely not driven by electric shocks.
The authors conclude that there are some suggestions for an association between Parkinson disease mortality and occupational exposure to extremely low-frequency magnetic fields. However, the weight given to these findings is limited by the absence of a monotonic trend with duration of exposure or cumulative exposure. No evidence for association between Parkinson disease mortality and occupational exposure to the risk of electric shocks was found.
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