研究のタイプ: 疫学研究 (observational study)

[オランダでの前向きコホートにおける職業ばく露とパーキンソン病の死亡率] epidem.

Occupational exposures and Parkinson's disease mortality in a prospective Dutch cohort.

掲載誌: Occup Environ Med 2015; 72 (6): 448-455

この研究は、オランダの人口ベースの大規模な前向きコホート研究において、6種類の職業ばく露(殺虫剤、有機溶剤、金属、ジーゼル車排気ガス、超低周波磁界(ELF-MF)、電撃)とパーキンソン病(PD)による死亡との関連を調査した。この調査の母体であるコホート調査は、1986年に55-69歳であった男性58276人、女性62573人を取り込み、2003年まで17.3年間、死因別の死亡率を追跡し、PDによる死亡(男性402人、女性207人)を確認した。このコホートから5000人を無作為に抽出したサブコホートにおいて、症例−コホート研究デザインで、PD死亡と各種職業ばく露との関連をCox回帰分析により評価した。職業ばく露評価は、職種ばく露マトリクスに基づいた。その結果、男性で、殺虫剤およびELF-MFへの過去のばく露が高かった群においてハザード比の上昇が見られたが、ばく露期間との関連や累積ばく露における傾向性は何も見られなかった;女性では、高ばく露群の数が少ないため結果は不安定であった、と報告している。

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研究の目的(著者による)

The association between the occupational exposure to extremely low-frequency magnetic fields, electrical shocks as well as other risk factors and the risk of Parkinson disease mortality was investigated in the Netherlands Cohort Study. Furthermore, the effects of combined exposure to these occupational risk factors were studied.

詳細情報

Following a case-cohort approach, a randomly selected subcohort (n=5000) was drawn.

影響評価項目/リスク推定のタイプ

リスク推定のタイプ: (hazard ratio)

ばく露

ばく露評価

ばく露集団

グループ 説明
参照集団 1 magnetic field exposure: background
集団 2 magnetic field exposure: low
集団 3 magnetic field exposure: high
参照集団 4 cumulative exposure: background
集団 5 cumulative exposure: 1st terzile
集団 6 cumulative exposure: 2nd terzile
集団 7 cumulative exposure: 3rd terzile
参照集団 8 electric shock risk: background
集団 9 electric shock risk: low
集団 10 electric shock risk: high
参照集団 11 electric shock; cumulative exposure: 1st terzile
集団 12 electric shock; cumulative exposure: 2nd terzile
集団 13 electric shock; cumulative exposure: 3rd terzile

調査対象集団

調査規模

タイプ
合計 120,852
その他:

17.3 years of follow-up

統計学的分析方法: ( 調整: )

結論(著者による)

Among men, an elevated hazard ratio was observed for high exposure to occupational extremely low-frequency magnetic fields (HR 1.54, CI 1.00-2.36) but neither association with exposure duration nor a trend in cumulative exposure were observed. No association between Parkinson disease mortality and occupational exposure to electric shocks was found. No significant associations between Parkinson disease mortality and occupational exposure to extremely low-frequency magnetic fields as well as electric shocks were observed among women.
When the analysis of exposure to extremely low-frequency magnetic fields was adjusted for risk of electric shocks, the association between high exposure to extremely low-frequency magnetic fields and Parkinson disease mortality became stronger (HR 1.81, CI 1.15-2.85). This suggests that, if the observed association between high exposure to extremely low-frequency magnetic fields and Parkinson disease risk is true, this is likely not driven by electric shocks.
The authors conclude that there are some suggestions for an association between Parkinson disease mortality and occupational exposure to extremely low-frequency magnetic fields. However, the weight given to these findings is limited by the absence of a monotonic trend with duration of exposure or cumulative exposure. No evidence for association between Parkinson disease mortality and occupational exposure to the risk of electric shocks was found.

研究助成

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