研究のタイプ: 医学/生物学の研究 (experimental study)

[耳下腺への携帯電話電磁放射の有害影響に対するローズマリー抽出物の保護的役割の組織学的および組織化学的研究] med./bio.

Histological and histochemical study of the protective role of rosemary extract against harmful effect of cell phone electromagnetic radiation on the parotid glands.

掲載誌: Acta Histochem 2016; 118 (5): 478-485

この研究は、アルビノ雄ラット(n=40)を用い、耳下腺への携帯電話電磁放射ばく露したラット耳下腺組織の変化を調べ、加えてローズマリー抽出物摂取群における同様の影響も調べた。ラット対照群、ローズマリー抽出物摂取群、携帯電話ばく露群、ローズマリー抽出物摂取+携帯電話ばく露群の4群(各n=10)に分け、ばく露終了後に耳下腺を摘出しで組織学的検査(光学および電子顕微鏡的観察)、酸化ストレスマーカの測定(マロンジアルデヒドMDA)、総抗酸化能(TAC))を行った。その結果、携帯電話ばく露群では、光学および電子顕微鏡的レベルの耳下腺組織構造変化が観察された;ローズマリー抽出物摂取+携帯電話ばく露群では、そのような組織像の変化が改善されていた、と報告している。(JEIC注:アブストラクトにはばく露パラメータの記述無し)

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研究目的(著者による)

The effects of exposure of rats to a 900 MHz electromagnetic field (GSM) on the histology and oxidative stress of the parotid glands and the protective role of rosemary extract should be investigated.

詳細情報

Rosemary has antioxidative and anti-inflammatory effects. However, its protective role against EMF induced oxidative stress has not been investigated to date.
40 rats were divided into 4 groups (n=10 each): 1) exposure to the electromagnetic field, 2) treatment with rosemary extract, 3) co-exposure to the electromagnetic field and rosemary extract, 4) control group.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 900 MHz
ばく露時間: 4 hours/day for 30 days

General information

220 mg/kg body weight rosemary extract was administered orally daily during the exposure period

ばく露1

主たる特性
周波数 900 MHz
ばく露時間 4 hours/day for 30 days
Additional information GSM
ばく露装置
ばく露の発生源/構造
  • セルラ-電話
チャンバの詳細 cage
ばく露装置の詳細 the mobile phone was placed over the cage of the animals, which was surrounded by aluminum foil to focus waves and shield the animals from external fields
Additional information non-EMF-exposed groups were held separately in a different room
パラメータ
測定量 種別 Method Mass 備考
電力 2 W peak - - -
電力密度 0.02 mW/cm² mean - - -
SAR 0.9 W/kg - - - -

Reference articles

  • Al-Damegh MA (2012): [従来型携帯電話からの電磁放射で誘発されたラット精巣障害と抗酸化剤であるビタミンCおよびEの保護作用]

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

Histological and ultrastructural examinations revealed changes in the EMF exposure group (group 1) compared to the control group (group 4) and rosemary extract group (group 2). In histology, cytoplasmic vacuoles, irregular outlines and darkly stained nuclei were observed in acini. Moreover, mucous release was increased and thick connective tissue septa with congested blood vessels were found.
The electron microscopy confirmed this indication with heterochromatic nuclei and damaged organelles as well as collagen fibers in the basement membrane being found.
In the co-exposure group (group 3), most histological and ultrastructural changes were reverted and exhibited the state of the control group.
The diameter and number of serous acini as well as the parenchyma/stroma ratio were significantly decreased in the EMF exposure group compared to the control group and co-exposure group.
In oxidative stress tests, lipid peroxidation was significantly increased while the total antioxidant capacity was significantly decreased in the exposure group compared to the control group and co-exposure group.
The authors conclude that an exposure of rats to a 900 MHz electromagnetic field (GSM) might alter the histology of the parotid glands possibly due to oxidative stress and that rosemary might play a protective role against this effect through its antioxidant activity.

研究の種別:

研究助成

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