研究のタイプ: 医学/生物学の研究 (experimental study)

[マウス精巣に対する2G携帯電話放射 (900 - 1900 MHz) への長期ばく露の影響] med./bio.

Effects of long term exposure to a 2G cell phone radiation (900 - 1900 MHz) on mouse testis.

掲載誌: Int J Sci Res (Raipur) 2014; 3 (9): 523-529

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研究目的(著者による)

The effects of chronic exposure of mice to a 900-1900 MHz electromagnetic field (2G) on testes should be investigated.

詳細情報

21-days-old mice were divided into the following groups (n=3 each): exposure to the electromagnetic field for 1) 30, 2) 60, 3) 90, 4) 120, 5) 150 and 6) 180 days. For each exposure group, a separate sham exposure group (n=3 mice each) was used. Mice were sacrificed 24 hours after the end of exposure, respectively.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 900–1,900 MHz
ばく露時間: intermittent 2 minutes every half an hour (total of 48 minutes per day) for 30 days
  • SAR: 1.69 W/kg
ばく露2: 900–1,900 MHz
ばく露時間: intermittent 2 minutes every half an hour (total of 48 minutes per day) for 60 days
  • SAR: 1.69 W/kg
ばく露3: 900–1,900 MHz
ばく露時間: intermittent 2 minutes every half an hour (total of 48 minutes per day) for 90 days
  • SAR: 1.69 W/kg
ばく露4: 900–1,900 MHz
ばく露時間: intermittent 2 minutes every half an hour (total of 48 minutes per day) for 120 days
  • SAR: 1.69 W/kg
ばく露5: 900–1,900 MHz
ばく露時間: intermittent 2 minutes every half an hour (total of 48 minutes per day) for 150 days
  • SAR: 1.69 W/kg
ばく露6: 900–1,900 MHz
ばく露時間: intermittent 2 minutes every half an hour (total of 48 minutes per day) for 180 days
  • SAR: 1.69 W/kg

ばく露1

主たる特性
周波数 900–1,900 MHz
タイプ
  • electromagnetic field
ばく露時間 intermittent 2 minutes every half an hour (total of 48 minutes per day) for 30 days
ばく露装置
ばく露の発生源/構造
  • セルラ-電話
  • 2G phone
チャンバの詳細 cages with a temperature of 22 ± 1°C and 60% relative humidity
ばく露装置の詳細 18 mice were exposed in a cage; cell phone was placed under cage roof at a distance of 5 cm to the floor; phone was put in non-vibrating, silent, do not disturb (DND) and auto answer activated mode and was rung upon from another cell phone
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
SAR 1.69 W/kg - 測定値 10 g -

ばく露2

主たる特性
周波数 900–1,900 MHz
タイプ
  • electromagnetic field
ばく露時間 intermittent 2 minutes every half an hour (total of 48 minutes per day) for 60 days
ばく露装置
ばく露の発生源/構造
  • E1と同じ装置
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
SAR 1.69 W/kg - 測定値 10 g -

ばく露3

主たる特性
周波数 900–1,900 MHz
タイプ
  • electromagnetic field
ばく露時間 intermittent 2 minutes every half an hour (total of 48 minutes per day) for 90 days
ばく露装置
ばく露の発生源/構造
  • E1と同じ装置
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
SAR 1.69 W/kg - 測定値 10 g -

ばく露4

主たる特性
周波数 900–1,900 MHz
タイプ
  • electromagnetic field
ばく露時間 intermittent 2 minutes every half an hour (total of 48 minutes per day) for 120 days
ばく露装置
ばく露の発生源/構造
  • E1と同じ装置
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
SAR 1.69 W/kg - 測定値 10 g -

ばく露5

主たる特性
周波数 900–1,900 MHz
タイプ
  • electromagnetic field
ばく露時間 intermittent 2 minutes every half an hour (total of 48 minutes per day) for 150 days
ばく露装置
ばく露の発生源/構造
  • E1と同じ装置
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
SAR 1.69 W/kg - 測定値 10 g -

ばく露6

主たる特性
周波数 900–1,900 MHz
タイプ
  • electromagnetic field
ばく露時間 intermittent 2 minutes every half an hour (total of 48 minutes per day) for 180 days
ばく露装置
ばく露の発生源/構造
  • E1と同じ装置
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
SAR 1.69 W/kg - 測定値 10 g -

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

Body weight was significantly reduced after 30, 60 and 120 days of exposure (groups 1, 2 and 4), mean testis weight was significantly reduced in all exposure groups except for group 4 and the mean testis volume was significantly reduced in groups 1-3 compared to sham exposed mice.
In histological analysis, the mean density of seminiferous tubules was significantly lower in all exposure groups except for group 1, the mean seminiferous tubule diameter was significantly reduced in all exposure group except for group 2, and the numbers of Sertoli cells/tubule and Leydig cells was significantly reduced in all exposure groups compared to the sham exposure groups.
For Johnson testicular biopsy score count and testosterone level all exposure groups were pooled and a significantly reduced serum testosterone level and mild histological changes compared to sham exposed animals were found.
The authors conclude that chronic exposure of mice to a 900-1900 MHz electromagnetic field (2G) might have detrimental effects on testes histology and function with possible consequences for fertility.

研究の種別:

研究助成

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