研究のタイプ: 医学／生物学の研究 (experimental study)

[30日間にわたる1日1時間の900MHz電磁界へのばく露によるラット精巣の組織病理および生化学的変化はない] med./bio.

Exposure to a 900 MHz electromagnetic field for 1 hour a day over 30 days does change the histopathology and biochemistry of the rat testis

著者: Odaci E, Ozyilmaz C
掲載誌: Int J Radiat Biol 2015; 91 (7): 547-554
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この研究は、成獣雄ラット（n=24）を対照群、擬似ばく露群、ばく露群に分け、ばく露群は、900MHz電磁界（EMF）の1日1時間のばく露を30日間受け、ばく露終了後、精巣の組織学的検査を行った。マロンジアルデヒド、スーパーオキシドジスムターゼ、カタラーゼ、グルタチオンのレベル、アポトーシス指数、組織病理学的損傷スコアを3つの群で比較した。その結果、EMFばく露群で、組織病理学的損傷が見られ、アポトーシス指数が高かった；マロンジアルデヒド、スーパーオキシドジスムターゼ、カタラーゼ、グルタチオンのレベルは、対照群に比べ、EMFばく露群では有意に低下した、と報告している。

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研究目的（著者による）

The effects of exposure of rats to a 900 MHz electromagnetic field on histology, oxidative stress and apoptosis in the testes should be investigated.

詳細情報

Rats were divided into 3 groups: 1) cage control (n=8), 2) sham exposure (n=7) and 3) exposure to the electromagnetic field (n=8).

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 900 MHz
ばく露時間: continuous for 1 hour/day for 30 days

ばく露1

主たる特性
周波数 900 MHz
タイプ
  • electromagnetic field
ばく露時間 continuous for 1 hour/day for 30 days
ばく露装置
ばく露の発生源／構造
チャンバの詳細 plexiglass jar (42 cm x 30 cm x 50 cm in size)
ばく露装置の詳細 all rats were exposed simultaneously in one jar; an oscillator was used to establish a 900 MHz field similar to the frequency of a mobile phone; a half-wave dipole antenna made from a copper rod (1 mm Œ 15 cm) was installed into the central region, approximately 11 cm inside the open surface of the jar; intensity of the exposure field was measured every day from 9 different points on the floor of the jar
Sham exposure A sham exposure was conducted.
Additional information electric field measurements were performed before each application and the absence of any other environmental electromagnetic field was confirmed before sham exposure and exposure were conducted
パラメータ
測定量 値 種別 Method Mass 備考
電界強度 10 V/m mean 測定値 - -
電力密度 0.265 W/m² mean 測定値および計算値 - -
SAR 0.025 W/kg - 測定値および計算値 whole body -
電力 300 mW - 推定値 - output power of power supply

Reference articles

  • Odaci E et al. (2015): [900 MHz電磁界の出生前ばく露が21日齢の雄ラットの腎臓に及ぼす病理学的影響]
  • Turedi S et al. (2015): [900MHz電磁界への出生前ばく露の21日齢雄ラットの心臓への影響]
  • Topal Z et al. (2015): [21日齢の新生仔雄ラットの肝臓に対する900 MHz電磁界への出生前の長時間ばく露の影響]
  • Hanci H et al. (2013): [21日齢のラットの精巣に対する900 MHz電磁界への出生前ばく露の影響]
  • Bas O et al. (2013): [出生前の妊娠13日から21日まで900メガヘルツ電磁界にばく露した32日齢の雌ラットのアンモン角の錐体細胞消失]
  • Ikinci A et al. (2013): [仔ラットの海馬の形態および学習行動に対する900メガヘルツ電磁界への出生前ばく露の影響]
  • Odaci E et al. (2013): [雌の仔ラットの脊髄の形態および運動行動に対する出生前の900メガヘルツ電磁界へのばく露の影響]

ばく露を受けた生物:

方法 影響評価項目／測定パラメータ／方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露後

研究の主なアウトカム（著者による）

The diameter and epithelium thickness of the seminiferous tubules were significantly lower, while the histopathological damage and apoptosis rate were significantly higher in the exposure group compared to the cage control and sham exposure. However, histopathological damage and the apoptosis rate in the sham exposure group were also significantly higher compared to the cage control but significantly lower in comparison to the exposure group.
The enzyme activities of catalase and superoxide dismutase, the amount of glutathione and lipid peroxidation were significantly decreased in the exposure group compared to the cage control. On the other hand, the enzyme activities of the catalase and superoxide dismutase and the amount of lipid peroxidation were significantly increased in the exposure group compared to the sham exposure group. In the sham exposure, the enzyme activity of the superoxide dismutase and the amount of glutathione and lipid peroxidation were significantly decreased compared to the cage control.
The significant differences in the sham exposure group in comparison to the cage control were probably stress-induced by the experimental procedure.
The authors conclude that exposure of rats to a 900 MHz electromagnetic field could alter histology, the oxidative status and apoptosis induction in the testes.

研究の種別:

研究助成

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