研究のタイプ: 医学/生物学の研究 (experimental study)

[電源周波数磁界の生物学的影響:ニワトリ胚の発達における神経化学的および毒物学的変化] med./bio.

Biological effects of power frequency magnetic fields: Neurochemical and toxicological changes in developing chick embryos.

掲載誌: Biomagn Res Technol 2004; 2 (1): 1

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研究目的(著者による)

The effects of exposure of chicken embryos to a 50 Hz magnetic field on neurotransmitter levels in the brain and tissue damage should be investigated.

詳細情報

Chicken embryos (eggs) were divided into the following groups: exposure to a magnetic field with 1) 5 µT, 2) 50 µT, 3) 100 µT and 4) a control group (remark EMF-Portal: group sizes not clear, probably n=12 each). 4 embryos of each group were investigated after 5, 10 and 15 days of exposure, respectively.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 50 Hz
ばく露時間: continuous for 5, 10 and 15 days
ばく露2: 50 Hz
ばく露時間: continuous for 5, 10 and 15 days
ばく露3: 50 Hz
ばく露時間: continuous for 5, 10 and 15 days

ばく露1

主たる特性
周波数 50 Hz
タイプ
  • magnetic field
波形
  • sinusoidal
ばく露時間 continuous for 5, 10 and 15 days
ばく露装置
ばく露の発生源/構造
チャンバの詳細 incubator
ばく露装置の詳細 a square-shaped Helmholtz coil was wound over a wooden frame of 25 Œ 25 Œ 25 cm3 and placed in an incubator; output voltage variation of coil supply was limited to less than 1% and field was uniform; to reduce the electric field in the exposure set up, the 230 V supply voltage was stepped down to 12V/15V using a transformer; all eggs maintained a uniform temperature of 35 ± 2°C
パラメータ
測定量 種別 Method Mass 備考
磁束密度 5 µT - - - ± 0.25 µT

ばく露2

主たる特性
周波数 50 Hz
タイプ
  • magnetic field
波形
  • sinusoidal
ばく露時間 continuous for 5, 10 and 15 days
ばく露装置
ばく露の発生源/構造
  • E1と同じ装置
パラメータ
測定量 種別 Method Mass 備考
磁束密度 50 µT - - - ± 2.5 µT

ばく露3

主たる特性
周波数 50 Hz
タイプ
  • magnetic field
波形
  • sinusoidal
ばく露時間 continuous for 5, 10 and 15 days
ばく露装置
ばく露の発生源/構造
  • E1と同じ装置
パラメータ
測定量 種別 Method Mass 備考
磁束密度 100 µT - - - ± 5 µT

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

There was a significant increase in the level of noradrenaline in the brain while there was a significant decrease in the tyrosine level after 15 days in all exposure groups compared to the control group.
The glutamine synthetase enzyme activity and the level of glutamine in the brain were significantly increased after 15 days in group 3 (100 µT) compared to the control group.
There were no significant differences between exposed eggs and the control group in the other parameters or at the other time points.
The authors conclude that exposure of chicken embryos to a 50 Hz magnetic field could affect noradrenaline and glutamate levels in the brain.

研究の種別:

研究助成

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