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To study the effect of mobile exposure on different regions of the rat brain.
Six animals were exposed and six animals were sham exposed.
|ばく露時間||continuous for 2 h/day on 45 days|
|Repetition frequency||216.7 Hz|
burst width: 0.577 ms
|ばく露装置の詳細||rats placed individually in 18 - 22 cm long, 5.7 cm high and 4 - 7 cm wide Plexiglas cages, fixed with anechoic material and ventilated with 1 cm diameter holes; mobile phone positioned on top of the cage; mobility of the rats in the cage limited to 1 - 2 cm; cell phones in stand-by mode (missed call); each missed call lasted 1 min, separated by 15 s intervals|
|Sham exposure||A sham exposure was conducted.|
The data showed a significant decrease in the enzyme activities of glutathione peroxidase and superoxide dismutase, and an increase in catalase enzyme activity. Protein kinase C enzyme activity was significantly decreased in the samples of the exposed group (hippocampus and whole brain). Also, a significant decrease in the level of pineal melatonin and a significant increase in creatine kinase and caspase 3 enzyme activities was observed in the exposed group (whole brain) compared with the sham exposed group. Finally, a significant increase in the level of reactive oxygen species was also recorded.
The authors conclude that a decrease or an increase in antioxidative enzyme activities, protein kinase C, melatonin, caspase 3, and creatine kinase enzyme activities are related to an overproduction of reactive oxygen species in the animals under mobile phone exposure.