研究のタイプ: 医学/生物学の研究 (experimental study)

[900 MHz電磁界への出生前の慢性ばく露は新生仔ラットの海馬の錐体細胞消失を生じる] med./bio.

Chronic prenatal exposure to the 900 megahertz electromagnetic field induces pyramidal cell loss in the hippocampus of newborn rats.

掲載誌: Toxicol Ind Health 2009; 25 (6): 377-384

妊娠ラット対照群(6匹)とばく露群(6匹)に無作為に分け、ばく露群は妊娠1日目から19日目まで900MHz電磁界ばく露を与えた。両群の新生仔を4週齢で屠殺し、海馬アンモン角の錐体細胞数を調べた結果、ばく露群から生まれた新生仔の方が有意に数が少なかったと報告している。

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研究目的(著者による)

To investigate the effects of prenatal exposure to 900 MHz electromagnetic fields on the postnatal development of the pyramidal cells of the cornu ammonis.

詳細情報

The cornu ammonis is a part of the hippocampus that involves short-term memory and learning.
Pregnant rats were assigned to a control group (n=3) and an exposure group (n=3). Exposure was performed during the 1-19th gestation day. Four weeks after delivery, randomly selected offspring of the control group (n=6) and the exposure group (n=6) was sacrificed for investigation.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 900 MHz
Modulation type: CW
ばく露時間: continuous during gestation (19 days)
  • SAR: 2 W/kg peak (whole body)
  • 電力密度: 1 mW/cm² average over time (+/- 0.4 mW/cm²)

ばく露1

主たる特性
周波数 900 MHz
タイプ
  • electromagnetic field
ばく露時間 continuous during gestation (19 days)
Modulation
Modulation type CW
ばく露装置
ばく露の発生源/構造
ばく露装置の詳細 whole body exposure in 12 cm long plastic tube cages with a diameter of 5.5 cm
パラメータ
測定量 種別 Method Mass 備考
SAR 2 W/kg peak - whole body -
電力密度 1 mW/cm² average over time 測定値 - +/- 0.4 mW/cm²

Reference articles

  • Yildiz M et al. (2006): [ラットの骨ミネラル密度に対する電磁界の影響並びにCAPEの防護効果]
  • Koyu A et al. (2005): [ラットのTSHおよび甲状腺ホルモンに対する900 MHz電磁界の影響]
  • Ozguner M et al. (2005): [電磁界にばく露した後のラットの生殖器官に対する生物学的および形態学的影響]

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

The prenatal 900 MHz exposure significantly reduced the total pyramidal cell number in the cornu ammonis in the offspring. In exposed rats pyramidal cells with dark neurons and shrunken perikaryon were seen at all depths of the cornu ammonis. The physical examination did not show skeletal anomalies or differences in body or brain weight between exposed and control groups.
It was concluded that prenatal exposure to 900 MHz electromagnetic fields plays a critical role in the neuronal formation in the hippocampus.

研究の種別:

研究助成

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