研究のタイプ: 医学／生物学の研究 (experimental study)

[マイクロ波照射はフィッシャーラットの脳に酸化ストレス、認知障害および炎症を誘導する] med./bio.

Microwave radiation induced oxidative stress, cognitive impairment and inflammation in brain of Fischer rats

著者: Megha K, Deshmukh PS, Banerjee BD, Tripathi AK, Abegaonkar MP
掲載誌: Indian J Exp Biol 2012; 50 (12): 889-896
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この研究は、ラットを用いた実験で、携帯電話に用いられるマイクロ波放射がラットの脳に生じさせる酸化ストレス、認知障害、および炎症の程度を評価した。オスのフィッシャー-344ラットに、900 MHzまたは1800 MHzのマイクロ波放射を30日間（2時間/日）与えた。それぞれのばく露におけるSAR は、5.953×10-4 W / kgおよび 5.835×10-4 W / kgであった。その結果、マイクロ波ばく露群では、擬似ばく露群に比べ、ラットの脳組織における認知機能の有意な障害および酸化ストレスの誘発が観察された；マイクロ波ばく露群では、ばく露後にサイトカイン（IL-6およびTNF-α）のレベルの有意な上昇が観察された、と報告している。

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研究目的（著者による）

To investigate the effects of an exposure to microwaves on cognitive performance as well as oxidative stress level and cytokine production in rats.

詳細情報

3 groups of rats were examined (n=6 per group): 1.) sham exposure, 2.) exposure to 900 MHz-electromagnetic field and 3.) exposure to 1800 MHz-electromagnetic field.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 900 MHz
ばく露時間: 2 h/day, 5 days a week for 30 days
ばく露2: 1,800 MHz
ばく露時間: 2 h/day, 5 days a week for 30 days

ばく露1

主たる特性
周波数 900 MHz
タイプ
  • electromagnetic field
ばく露時間 2 h/day, 5 days a week for 30 days
ばく露装置
ばく露の発生源／構造
  • GTEMセル
Distance between exposed object and exposure source 1 m
チャンバの詳細 during exposure rats were restrained in a closed box (30 cm x 20 cm x15 cm) divided in 4 compartements with holes of 1 cm for ventilation; 6 rats were placed within the device in two such boxes simultaneously
ばく露装置の詳細 GTEM cell was a pyramidal tapered, dual terminated section with outer cell dimension of 220 cm Œ 120 cm Œ 80 cm; microwave chamber was lined with absorbers to minimize reflections
Sham exposure A sham exposure was conducted.
パラメータ
測定量 値 種別 Method Mass 備考
SAR 0.5953 mW/kg mean 計算値 - -
電力密度 1.68 W/m² - - - -
電力 0.2408 mW - - - received by the animals
測定および計算の詳細

Although exposure setup was identical to the one used in this article (Deshmukh et al.), SAR values are different and the difference is not comprehensible. (Remark EMF-Portal)

ばく露2

主たる特性
周波数 1,800 MHz
タイプ
  • electromagnetic field
ばく露時間 2 h/day, 5 days a week for 30 days
ばく露装置
ばく露の発生源／構造
  • E1と同じ装置
パラメータ
測定量 値 種別 Method Mass 備考
SAR 0.5835 mW/kg mean 計算値 - -
電力密度 1.72 W/m² - - - -
電力 0.2408 mW - - - received by the animals

Reference articles

  • Ardoino L et al. (2005): [電磁界の生物学的影響の研究を目的としたIn vivoパイロット試験用の無線周波システム]

ばく露を受けた生物:

方法 影響評価項目／測定パラメータ／方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露中
  • ばく露後

研究の主なアウトカム（著者による）

In the elevated plus maze and the Morris water maze, the spatial memory and learning was significantly decreased in the exposed groups in comparison to the sham exposed group. No significant differences occurred between the exposure groups.
In the exposed group the levels of the lipid oxidation and protein oxidation as well as the levels of interleukin-6 and tumor necrosis factor alpha were significantly increased and the level of reduced glutathione was significantly decreased compared to the sham exposed group.
The authors conclude that exposure to microwaves could lead to cognitive impairments in rats and that these effects could be due to an increased oxidative stress level.

研究の種別:

研究助成

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