研究のタイプ: 医学/生物学の研究 (experimental study)

[ラット脳の構造と機能に対する携帯電話電磁界放射(900 MHz 無線周波)の影響] med./bio.

Effects of mobile phone radiation (900 MHz radiofrequency) on structure and functions of rat brain.

掲載誌: Neurol Res 2014; 36 (12): 1072-1079

この研究は、ラット(30日齢)に、携帯電話ハンドセットを用いて900MHz電磁界ばく露を1日4時間、15日間与え、ばく露終了後に不安・空間学習記憶行動テストを実施し、その後摘出した脳組織標本で脳の抗酸化状態、構造上の変化を評価した。その結果、ばく露群では、対照群および擬似対照群に比べ、行動上の変化として不安の亢進および学習の低下が観察された;ばく露群では、抗酸化酵素レベルの変化、脂質過酸化の増加が観察された;海馬の一部および皮質神経変性した細胞が観察された、と報告している。

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研究目的(著者による)

The effects of exposure of rats to a 900 MHz electromagnetic field on the behavior, oxidative stress and neuronal damage in the brain should be investigated.

詳細情報

The rats were divided into 5 groups: 1) cage control (n=3 for each exposure group, total of n=9), 2) sham exposure (n=3 for each exposure group) and the exposure groups for 3) behavioral, 4) biochemical and 5) histological analysis (n=7 each).

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 900 MHz
ばく露時間: continuous for 4 h/day for 15 days
  • SAR: 0.99 W/kg mean (other specification: ca. 0.9 W/kg (?))

ばく露1

主たる特性
周波数 900 MHz
タイプ
  • electromagnetic field
ばく露時間 continuous for 4 h/day for 15 days
ばく露装置
ばく露の発生源/構造
  • セルラ-電話
チャンバの詳細 plexiglass boxes with ventilation holes of 1 cm diameter on all sides
ばく露装置の詳細 mobile phone (Spice S-5110) was fitted to the roof of the cage from the inside; temperature was maintained at 25 ± 2°C
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
SAR 0.99 W/kg mean 計算値 - other specification: ca. 0.9 W/kg (?)

Reference articles

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

No significant differences were observed between sham exposure (group 2) and cage control (group 1) animals in any parameter.
In the open field test, exposed animals (group 3) showed a significantly different behavior compared to the cage control, indicating a higher degree of anxiety and stress. However, in the elevated plus maze, group 3 showed a significantly different behavior compared to the cage control which indicated reduced anxiety.
In the Morris water maze, group 3 exhibited a significant impairment of their spatial memory compared to groups 1 and 2.
The superoxide dismutase and catalase enzyme activities were significantly decreased in the brain and liver of exposed animals (group 4) compared to the cage control. The level of reduced glutathione was significantly decreased in the brain and significantly increased in the liver of animals of group 4 compared to the cage control. The ascorbic acid level was significantly increased in the liver of animals of group 4 compared to the cage control, as was the amount of malondialdehyde in the brain and liver.
Histopathology showed a distinctly greater amount of degenerated neurons in the hippocampus of exposed animals (group 5) than in the cage control and sham exposure.
The authors conclude that exposure of rats to a 900 MHz electromagnetic field could provoke neuronal damage and oxidative stress in the brain, which in turn results in a changed behavior.

研究の種別:

研究助成

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