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To study the effects of exposure to a 50 Hz electric field on plasma level of triacylglycerol, free fatty acids, total cholesterol and phospholipid and mRNA expression of diacylglycerol acyltransferase genes (which encode enzymes involved in the synthesis of triacylglycerol ) in liver and intestines from mice.
Six mice were exposed and six mice were sham exposed.
ばく露時間: continuous for 30 min/day for 11 days
|ばく露時間||continuous for 30 min/day for 11 days|
|ばく露装置の詳細||20 cm high cylindrical plastic cage with a diameter of 20 cm (with 10 cm long and 0,5 cm wide slits at 5 mm intervals); 1m x 60 cm stainless steel electrodes on top and at the bottom of the cage|
|Sham exposure||A sham exposure was conducted.|
|電界強度||45 kV/m||effective value||測定値||-||-|
The diacylglycerol-o-acyltransferase gene 2 (DGAT2) expression in the liver of exposed mice was significantly lower than that of the control. Additionally, both plasma total cholesterol and phospholipid in the exposed mice were lower than those in the control. However, there was no difference in DGAT1 expression, triacylglycerol or free fatty acid levels.
The mechanisms for the effects of electric fields on lipid metabolism are not well understood yet, but altered DGAT2 activity may be involved.