この研究は、Wistarアルビノ雄ラット40匹を10匹ずつの4群（対照群；メラトニン投与（Mel）群；マイクロ波（MW）ばく露群；メラトニン投与＋MWばく露（MW+Mel）群）に分け、MWとメラトニンが体重と行動に与える影響を調べた。MWばく露は、プラスティックケースに入れた携帯電話をプラスティック製ケージ内に置いて、1日4時間、60日間行った。メラトニン2 mg/kgは、60日間毎日、腹腔内注射した（対照群には生食液投与を同様に行った）。その結果、対照群に比べMW群では20、4、60日目の体重が少なかった；一方、MW群に比べMW+Mel群では20日目以降の体重が有意に多かった；MW群ではストレス行動が示されたが、ばく露後その行動は観察されなかった；MW+Mel群ではストレス行動は少なかった、などの所見を報告している。
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To determine body mass and behaviour changes in rats after a chronic microwave exposure with and without melatonin treatment.
Rats were divided into 4 groups (n= 10 per group): 1.) control group treated with 0.9 % saline, 2.) treated with melatonin (2 mg/kg per day), 3.) exposed and 4.) exposed + melatonin (2 mg/kg per day).
Rats were divided into the following four groups: i) control group ii) treated with melatonin (2 mg/kg per day) iii) microwave exposure iv) melatonin treatment + microwave exposure
| 周波数 | 900 MHz |
|---|---|
| タイプ |
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| 特性 |
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| ばく露時間 | continuous for 4 h/day on 60 days |
| Modulation type | CW |
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| ばく露の発生源／構造 |
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|---|---|
| ばく露装置の詳細 | eight rats placed in a plastic cage during exposure; mobile phone positioned in the cage's center in a special compartment with the antenna pointing downwards; cage placed on absorbing rubber material with a wooden surface |
Significant body mass reduction was noted in exposed animals when compared to the control group after 20, 40 and 60 days. An administration of melatonin (group 2) caused a significant increase in body weight after 20 days in comparison to the control group. Exposed rats, treated with melatonin, showed a significant increase in body mass after 20 days when compared to the exposed rats.
After 10 days of exposure, changes in the behavior of the rats occurred, which became more intensive with a maximum after 60 days: In both exposure groups, a reduced locomotor activity was noticed in comparison to the unexposed groups, but no differences between the exposure group with melatonin administration and the exposure group without melatonin administration occurred. The exposed animals, not treated with melatonin, showed more anxiety and agitation (more grooming, moving away from the source of exposure) and less exploratory behavior (less rearing) than the unexposed groups. The exposed animals treated with melatonin, showed less stress compared to the exposed rats without melatonin administration.
The authors conclude that microwave exposure could cause a body mass decrease and anxiety related behavior. However, treatment with melatonin could cause a reverse of those effects.
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