研究のタイプ: 医学/生物学の研究 (experimental study)

[携帯電話からのマイクロ波放射へのばく露中のラットの体質量及び行動に対するメラトニンの影響] med./bio.

The effect of melatonin on body mass and behaviour of rats during an exposure to microwave radiation from mobile phone.

掲載誌: Bratisl Lek Listy 2012; 113 (5): 265-269

この研究は、Wistarアルビノ雄ラット40匹を10匹ずつの4群(対照群メラトニン投与(Mel)群;マイクロ波MWばく露群;メラトニン投与+MWばく露MW+Mel)群)に分け、MWとメラトニンが体重と行動に与える影響を調べた。MWばく露は、プラスティックケースに入れた携帯電話をプラスティック製ケージ内に置いて、1日4時間、60日間行った。メラトニン2 mg/kgは、60日間毎日、腹腔内注射した(対照群には生食液投与を同様に行った)。その結果、対照群に比べMW群では20、4、60日目の体重が少なかった;一方、MW群に比べMW+Mel群では20日目以降の体重が有意に多かった;MW群ではストレス行動が示されたが、ばく露後その行動は観察されなかった;MW+Mel群ではストレス行動は少なかった、などの所見を報告している。

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研究目的(著者による)

To determine body mass and behaviour changes in rats after a chronic microwave exposure with and without melatonin treatment.

詳細情報

Rats were divided into 4 groups (n= 10 per group): 1.) control group treated with 0.9 % saline, 2.) treated with melatonin (2 mg/kg per day), 3.) exposed and 4.) exposed + melatonin (2 mg/kg per day).

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 900 MHz
Modulation type: CW
ばく露時間: continuous for 4 h/day on 60 days

General information

Rats were divided into the following four groups: i) control group ii) treated with melatonin (2 mg/kg per day) iii) microwave exposure iv) melatonin treatment + microwave exposure

ばく露1

主たる特性
周波数 900 MHz
タイプ
  • electromagnetic field
特性
  • near field
ばく露時間 continuous for 4 h/day on 60 days
Modulation
Modulation type CW
ばく露装置
ばく露の発生源/構造
  • Nokia 3110 GSM mobile phone
ばく露装置の詳細 eight rats placed in a plastic cage during exposure; mobile phone positioned in the cage's center in a special compartment with the antenna pointing downwards; cage placed on absorbing rubber material with a wooden surface
パラメータ
測定量 種別 Method Mass 備考
電界強度 9.88 V/m minimum 測定値 - -
電界強度 18.35 V/m maximum 測定値 - -
磁束密度 4.68 µT minimum 測定値 - -
磁束密度 8.69 µT maximum 測定値 - -
SAR 0.043 W/kg minimum 計算値 whole body -
SAR 0.135 W/kg maximum 計算値 whole body -

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露中
  • ばく露後

研究の主なアウトカム(著者による)

Significant body mass reduction was noted in exposed animals when compared to the control group after 20, 40 and 60 days. An administration of melatonin (group 2) caused a significant increase in body weight after 20 days in comparison to the control group. Exposed rats, treated with melatonin, showed a significant increase in body mass after 20 days when compared to the exposed rats.
After 10 days of exposure, changes in the behavior of the rats occurred, which became more intensive with a maximum after 60 days: In both exposure groups, a reduced locomotor activity was noticed in comparison to the unexposed groups, but no differences between the exposure group with melatonin administration and the exposure group without melatonin administration occurred. The exposed animals, not treated with melatonin, showed more anxiety and agitation (more grooming, moving away from the source of exposure) and less exploratory behavior (less rearing) than the unexposed groups. The exposed animals treated with melatonin, showed less stress compared to the exposed rats without melatonin administration.
The authors conclude that microwave exposure could cause a body mass decrease and anxiety related behavior. However, treatment with melatonin could cause a reverse of those effects.

研究の種別:

研究助成

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