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To determine body mass and behaviour changes in rats after a chronic microwave exposure with and without melatonin treatment.
Rats were divided into 4 groups (n= 10 per group): 1.) control group treated with 0.9 % saline, 2.) treated with melatonin (2 mg/kg per day), 3.) exposed and 4.) exposed + melatonin (2 mg/kg per day).
Rats were divided into the following four groups: i) control group ii) treated with melatonin (2 mg/kg per day) iii) microwave exposure iv) melatonin treatment + microwave exposure
|ばく露時間||continuous for 4 h/day on 60 days|
|ばく露装置の詳細||eight rats placed in a plastic cage during exposure; mobile phone positioned in the cage's center in a special compartment with the antenna pointing downwards; cage placed on absorbing rubber material with a wooden surface|
Significant body mass reduction was noted in exposed animals when compared to the control group after 20, 40 and 60 days. An administration of melatonin (group 2) caused a significant increase in body weight after 20 days in comparison to the control group. Exposed rats, treated with melatonin, showed a significant increase in body mass after 20 days when compared to the exposed rats.
After 10 days of exposure, changes in the behavior of the rats occurred, which became more intensive with a maximum after 60 days: In both exposure groups, a reduced locomotor activity was noticed in comparison to the unexposed groups, but no differences between the exposure group with melatonin administration and the exposure group without melatonin administration occurred. The exposed animals, not treated with melatonin, showed more anxiety and agitation (more grooming, moving away from the source of exposure) and less exploratory behavior (less rearing) than the unexposed groups. The exposed animals treated with melatonin, showed less stress compared to the exposed rats without melatonin administration.
The authors conclude that microwave exposure could cause a body mass decrease and anxiety related behavior. However, treatment with melatonin could cause a reverse of those effects.