研究のタイプ: 医学／生物学の研究 (experimental study)

[異なる年齢の幼若ラットの左右大脳皮質での活性酸素種代謝に対する950MHz超高周波電磁放射への慢性ばく露の影響] med./bio.

Effects of chronic exposure to 950 MHz ultra-high-frequency electromagnetic radiation on reactive oxygen species metabolism in the right and left cerebral cortex of young rats of different ages

著者: Furtado-Filho OV, Borba JB, Maraschin T, Souza LM, Henriques JA, Moreira JC, Saffi J
掲載誌: Int J Radiat Biol 2015; 91 (11): 891-897
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この研究は、幼若ラット（新生仔および6日齢仔：各12匹）の左右大脳皮質（LCCおよびRCC）におけるDNA、タンパク質および脂質の酸化的損傷のバイオマーカに対する950MHz超高周波電磁放射（UHF-EMR）への慢性ばく露（1日1時間、全妊娠期間中または最大27日間）の影響を調べた。新生仔は全妊娠期間中ばく露を受けた。6日齢仔は全妊娠期間および出生後6日間ばく露を受けた。ばく露終了後に、ばく露群および対照群の大脳皮質組織を検査した。UHF-EMRのSARは1.32 – 1.14W/kgであった。その結果、新生仔では検査したバイオマーカに何も変化が無かった；6日齢仔では、RCCのカルボニル化タンパク質のレベルが上昇し、血中グルコース濃度が低下していた、と報告している。

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研究目的（著者による）

The effects of a prenatal and postnatal exposure of rats to a 950 MHz electromagnetic field on oxidative damages of DNA, proteins and lipids in the cortex should be investigated.

詳細情報

Pregnant rats were divided into two groups (exposure and sham exposure, n=6 each) and were (sham) exposed from the first day of pregnancy until up to 6 days after birth of the pups. Directly after birth and 6 days thereafter, 6 pups from exposed dams and 6 pups from sham exposed dams were killed and investigated, respectively.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 950 MHz
ばく露時間: continuous for 30 min/day from the first day of gestation until birth
ばく露2: 950 MHz
ばく露時間: continuous for 30 min/day from the first day of gestation until 6 days after birth

General information

further exposure reference: Sadiku, 2010: Elements of electromagnetics. 5th edition. London, UK: Oxford University Press.

ばく露1

主たる特性
周波数 950 MHz
タイプ
  • electromagnetic field
ばく露時間 continuous for 30 min/day from the first day of gestation until birth
Additional information vertical polarization
ばく露装置
ばく露の発生源／構造
チャンバの詳細 polypropylene boxes (40.5 x 33.3 x 17.5 cm)
ばく露装置の詳細 boxes were placed 11 cm away from the antenna; exposure system was kept in an aluminium Faraday cage (101.5 x 64.0 x 38.0 cm; 0.5 cm mesh); cages were placed on a wooden tray
Sham exposure A sham exposure was conducted.
Additional information the cage with the sham-exposed group was placed 92 cm away from the cage of the exposure group
パラメータ
測定量 値 種別 Method Mass 備考
電界強度 35 V/m spatial average 測定値 - -
電界強度 52.1 V/m maximum 測定値 - -
電界強度 13.5 V/m minimum 測定値 - -
電力 1 W - - - -
SAR 1.32 W/kg - 計算値 - for pups on day of birth
電界強度 32.8 V/m - 計算値 - internal electric field in the brain of newborn rats
SAR 0.44 W/kg - 計算値 - for dams on first day of gestation
Additional parameter details

the electric field strength outside the cage was 0.3 V/m; the electric field strength in the sham exposure cage was 0.15 V/m and the SAR the for the sham exposure group was 2.4 x 10-5 W/kg; static magnetic field was 0.12 µT

ばく露2

主たる特性
周波数 950 MHz
タイプ
  • electromagnetic field
ばく露時間 continuous for 30 min/day from the first day of gestation until 6 days after birth
Additional information vertical polarization
ばく露装置
ばく露の発生源／構造
  • E1と同じ装置
Sham exposure A sham exposure was conducted.
パラメータ
測定量 値 種別 Method Mass 備考
電界強度 35 V/m spatial average 測定値 - -
電界強度 52.1 V/m maximum 測定値 - -
電界強度 13.5 V/m minimum 測定値 - -
電力 1 W - - - -
SAR 1.14 W/kg - 計算値 - for pups on day 6 of birth
SAR 0.35 W/kg - 計算値 - for dams on day 6 after birth
電界強度 33.8 V/m - 計算値 - internal electric field in brain of 6 day old pups

Reference articles

  • Furtado-Filho OV et al. (2014): [異なる年齢の若いラットの肝臓における酸化的損傷、不飽和脂肪酸および坑酸化物質の代謝に対する950 MHzのUHF電磁界放射の影響]
  • Peyman A et al. (2001): [マイクロ波周波数でのラット組織の誘電特性の年齢の関数としての変化]

ばく露を受けた生物:

方法 影響評価項目／測定パラメータ／方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露後

研究の主なアウトカム（著者による）

Newborn rats from exposed dams had a significantly reduced body weight in comparison to rats from sham exposed dams.
6-day-old exposed rats showed a significantly higher amount of carbonyl proteins in the right cortex and a significantly lower blood glucose level compared to the sham exposure group.
All other parameters did not show any significant differences between the exposure groups and the respective sham exposure groups.
The authors conclude that a prenatal and postnatal exposure of rats to a 950 MHz electromagnetic field does not seem to induce oxidative damages of DNA, proteins and lipids in the cortex.

研究の種別:

研究助成

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