研究のタイプ: 医学/生物学の研究 (experimental study)

[ラットのアルツハイマー病に対する超低周波電磁界ばく露の短期的影響] med./bio.

Short-term effects of extremely low frequency electromagnetic fields exposure on Alzheimer's disease in rats.

掲載誌: Int J Radiat Biol 2015; 91 (1): 28-34

この研究は、SD雄ラット(n=20)を用いて超低周波電磁界(ELF-EMFばく露記憶障害の関係を調べた。12週齢のラットばく露群、擬似ばく露群(それぞれn=10)に無作為に分け、100μT、50HzのELF-EMFに12週間、ばく露擬似ばく露)した後、モーリス水迷路(MWM)により認知および記憶の能力の変化を測定し、また、大脳皮質海馬血漿のアミロイドβ(Aβ)含有量を測定した。その結果、ばく露群、擬似ばく露群で、ばく露終了後の体重に有意差はなかった;認知ならびに記憶の障害、またAβ含有量や組織学的変化にも両群で違いはなかった、と報告している。

The detailed summary of this article is not available in your language or incomplete. Would you like to see a complete translation of the summary? Then please contact us →

研究目的(著者による)

To examine the influence of exposure to extremely low frequency magnetic fields on memory impairment in rats.

詳細情報

Rats were exposed (n=10) or sham exposed (n=10).
At the end of the exposure period, rats were subjected to the Morris water maze. Afterwards, they were killed to remove the brain and take blood samples.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 50 Hz
ばく露時間: continuous for 12 weeks

ばく露1

主たる特性
周波数 50 Hz
タイプ
  • magnetic field
ばく露時間 continuous for 12 weeks
ばく露装置
ばく露の発生源/構造
チャンバの詳細 rats were placed in a special plastic box without metallic parts; animals were able to move freely in the box
ばく露装置の詳細 coil of Helmholtz with two parallel spires (5.2 m Œ 5.2 m) was used; distance between two coils was 2 m, and one was buried underground for 0.7 m
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
磁束密度 100 µT - 測定値 - -

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
調査の時期:
  • ばく露前
  • ばく露後

研究の主なアウトカム(著者による)

No significant differences were observed in the body weight, histopathological examination of the brain, content of beta-amyloid protein, and the performance in the Morris water maze between exposed and sham exposed rats.
The results indicate that exposure to extremely low frequency magnetic fields has no influence on the memory performance of rats.

研究の種別:

研究助成

関連論文